Therapy of Ischemic Cerebral Vascular Disease Due to Atherothrombosis

J. Philip Kistler, Allan H. Ropper, Roberto C. Heros

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Therapy for Transient Ischemic Attacks Surgical Therapy Carotid endarterectomy remains the mainstay of the therapy for TIAs that are caused by carotid stenosis. First introduced in 1954 by Eastcott et al.,104 the procedure has been associated with a morbidity ranging from 1 to 20 per cent, depending largely on the patient population and the experience of the surgeon. 42,55,105 106 107 108 109 Although many studies suggest that this procedure is effective in preventing additional TIAs or strokes,55,105 106 107,109,110 its value is yet to be confirmed by a well-designed, controlled, randomized clinical trial. In the one multicenter controlled study published thus far, 24 centers randomly assigned.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jul 12 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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