Therapeutics targeting the inflammasome after central nervous system injury

Juan Pablo De Rivero Vaccari; W. Dalton Dietrich; Robert W. Keane

doi:10.1016/j.trsl.2015.05.003

Therapeutics targeting the inflammasome after central nervous system injury

Juan Pablo De Rivero Vaccari, W. Dalton Dietrich, Robert W. Keane

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

Innate immunity is part of the early response of the body to deal with tissue damage and infections. Because of the early nature of the innate immune inflammatory response, this inflammatory reaction represents an attractive option as a therapeutic target. The inflammasome is a component of the innate immune response involved in the activation of caspase 1 and the processing of pro-interleukin 1β. In this article, we discuss the therapeutic potential of the inflammasome after central nervous system (CNS) injury and stroke, as well as the basic knowledge we have gained so far regarding inflammasome activation in the CNS. In addition, we discuss some of the therapies available or under investigation for the treatment of brain injury, spinal cord injury, and stroke.

Original language	English (US)
Journal	Translational Research
DOIs	https://doi.org/10.1016/j.trsl.2015.05.003
State	Accepted/In press - Mar 23 2015

ASJC Scopus subject areas

Medicine(all)
Biochemistry, medical
Public Health, Environmental and Occupational Health

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De Rivero Vaccari, J. P., Dietrich, W. D., & Keane, R. W. (Accepted/In press). Therapeutics targeting the inflammasome after central nervous system injury. Translational Research. https://doi.org/10.1016/j.trsl.2015.05.003

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