Abstract
The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the Annual Conference on Engineering in Medicine and Biology |
| Place of Publication | Piscataway, NJ, United States |
| Publisher | Publ by IEEE |
| Pages | 671-672 |
| Number of pages | 2 |
| Edition | pt 2 |
| ISBN (Print) | 0879425598 |
| State | Published - Dec 1 1990 |
| Externally published | Yes |
| Event | Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA Duration: Nov 1 1990 → Nov 4 1990 |
Other
| Other | Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
|---|---|
| City | Philadelphia, PA, USA |
| Period | 11/1/90 → 11/4/90 |
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ASJC Scopus subject areas
- Bioengineering
Cite this
Therapeutic vascular systems. / Clark, H. G.; Agrawal, C. M.; Stack, R. S.
Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Piscataway, NJ, United States : Publ by IEEE, 1990. p. 671-672.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Therapeutic vascular systems
AU - Clark, H. G.
AU - Agrawal, C. M.
AU - Stack, R. S.
PY - 1990/12/1
Y1 - 1990/12/1
N2 - The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.
AB - The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.
UR - http://www.scopus.com/inward/record.url?scp=0025548108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025548108&partnerID=8YFLogxK
M3 - Conference contribution
SN - 0879425598
SP - 671
EP - 672
BT - Proceedings of the Annual Conference on Engineering in Medicine and Biology
PB - Publ by IEEE
CY - Piscataway, NJ, United States
ER -