TY - GEN
T1 - Therapeutic vascular systems
AU - Clark, H. G.
AU - Agrawal, C. M.
AU - Stack, R. S.
PY - 1990/12/1
Y1 - 1990/12/1
N2 - The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.
AB - The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.
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M3 - Conference contribution
AN - SCOPUS:0025548108
SN - 0879425598
T3 - Proceedings of the Annual Conference on Engineering in Medicine and Biology
SP - 671
EP - 672
BT - Biomedical Engineering Perspectives
PB - Publ by IEEE
T2 - Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Y2 - 1 November 1990 through 4 November 1990
ER -