Therapeutic vascular systems

H. G. Clark, C. M. Agrawal, R. S. Stack

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.

Original languageEnglish
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
Place of PublicationPiscataway, NJ, United States
PublisherPubl by IEEE
Pages671-672
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - Dec 1 1990
Externally publishedYes
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

Fingerprint

Polyglactin 910
glycolic acid
Nylons
Lactic acid
Engineering research
Copolymers
Tissue
Mechanical properties
Acids
Water
Testing
poly(lactic acid)

ASJC Scopus subject areas

  • Bioengineering

Cite this

Clark, H. G., Agrawal, C. M., & Stack, R. S. (1990). Therapeutic vascular systems. In Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 671-672). Piscataway, NJ, United States: Publ by IEEE.

Therapeutic vascular systems. / Clark, H. G.; Agrawal, C. M.; Stack, R. S.

Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Piscataway, NJ, United States : Publ by IEEE, 1990. p. 671-672.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Clark, HG, Agrawal, CM & Stack, RS 1990, Therapeutic vascular systems. in Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, Publ by IEEE, Piscataway, NJ, United States, pp. 671-672, Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Philadelphia, PA, USA, 11/1/90.
Clark HG, Agrawal CM, Stack RS. Therapeutic vascular systems. In Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Piscataway, NJ, United States: Publ by IEEE. 1990. p. 671-672
Clark, H. G. ; Agrawal, C. M. ; Stack, R. S. / Therapeutic vascular systems. Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Piscataway, NJ, United States : Publ by IEEE, 1990. pp. 671-672
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