Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women

A. Zarate, E. S. Canales, J. Soria, G. Forsbach, A. J. Kastin, Andrew V Schally

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.

Original languageEnglish
Pages (from-to)1233-1239
Number of pages7
JournalFertility and Sterility
Volume27
Issue number11
StatePublished - Dec 1 1976
Externally publishedYes

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Follicle Stimulating Hormone
Therapeutic Uses
Gonadotropin-Releasing Hormone
Ovulation
Clomiphene
Ovarian Hyperstimulation Syndrome
Contraception
Infertility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women. / Zarate, A.; Canales, E. S.; Soria, J.; Forsbach, G.; Kastin, A. J.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 27, No. 11, 01.12.1976, p. 1233-1239.

Research output: Contribution to journalArticle

Zarate, A, Canales, ES, Soria, J, Forsbach, G, Kastin, AJ & Schally, AV 1976, 'Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women', Fertility and Sterility, vol. 27, no. 11, pp. 1233-1239.
Zarate, A. ; Canales, E. S. ; Soria, J. ; Forsbach, G. ; Kastin, A. J. ; Schally, Andrew V. / Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women. In: Fertility and Sterility. 1976 ; Vol. 27, No. 11. pp. 1233-1239.
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