Abstract
Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.
| Original language | English |
|---|---|
| Pages (from-to) | 1233-1239 |
| Number of pages | 7 |
| Journal | Fertility and Sterility |
| Volume | 27 |
| Issue number | 11 |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women. / Zarate, A.; Canales, E. S.; Soria, J.; Forsbach, G.; Kastin, A. J.; Schally, Andrew V.
In: Fertility and Sterility, Vol. 27, No. 11, 01.12.1976, p. 1233-1239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women
AU - Zarate, A.
AU - Canales, E. S.
AU - Soria, J.
AU - Forsbach, G.
AU - Kastin, A. J.
AU - Schally, Andrew V
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.
AB - Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017106837&partnerID=8YFLogxK
M3 - Article
C2 - 824160
AN - SCOPUS:0017106837
VL - 27
SP - 1233
EP - 1239
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 11
ER -