Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women

A. Zarate; E. S. Canales; J. Soria; G. Forsbach; A. J. Kastin; A. V. Schally

doi:10.1016/s0015-0282(16)42188-6

Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women

A. Zarate, E. S. Canales, J. Soria, G. Forsbach, A. J. Kastin, A. V. Schally

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.

Original language	English (US)
Pages (from-to)	1233-1239
Number of pages	7
Journal	Unknown Journal
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/s0015-0282(16)42188-6
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women",

abstract = "Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.",

author = "A. Zarate and Canales, {E. S.} and J. Soria and G. Forsbach and Kastin, {A. J.} and Schally, {A. V.}",

year = "1976",

doi = "10.1016/s0015-0282(16)42188-6",

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T1 - Therapeutic use of gonadoliberin (follicle stimulating hormone/luteinizing hormone releasing hormone) in women

AU - Zarate, A.

AU - Canales, E. S.

AU - Soria, J.

AU - Forsbach, G.

AU - Kastin, A. J.

AU - Schally, A. V.

PY - 1976

Y1 - 1976

N2 - Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.

AB - Certain conclusions may be drawn from the present review. Synthetic FSH/LH RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH RH because of individual variations in response. Gonadoliberin may also be used to induce ovulation after follicular maturation has been evoked by other agents. FSH/LH RH can be utilized for supplementing the LH surge after clomiphene therapy in cases of clomiphene failure. When associated with HMG, the synthetic decapeptide may be helpful in avoiding the ovarian hyperstimulation syndrome. The 'triggering' of ovulation by a continuous infusion of FSH/LH RH might be a convenient means of controlling the timing of ovulation. It is expected that FSH/LH RH blocking analogs may be used to inhibit both LH and FSH release induced by endogenous gonadoliberin in women seeking contraception.

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