Therapeutic Trials in Muscular Dystrophy: III. Studies of Microbial Proteinase Inhibitors in Murine Dystrophy

Akira Enomoto, Walter G. Bradley

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalArchives of neurology
Volume34
Issue number12
DOIs
StatePublished - Dec 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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