The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.
|Original language||English (US)|
|Number of pages||3|
|Journal||Archives of neurology|
|State||Published - Dec 1977|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology