Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy

A. Enomoto, Walter G Bradley

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.

Original languageEnglish
Pages (from-to)771-773
Number of pages3
JournalArchives of Neurology
Volume34
Issue number12
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Muscular Dystrophies
Antipain
Peptide Hydrolases
Muscles
Sarcolemma
Liposomes
Chickens
Therapeutics
pepstatin
Fiber
leupeptin
Degeneration
Chicken
Tissue Culture

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy. / Enomoto, A.; Bradley, Walter G.

In: Archives of Neurology, Vol. 34, No. 12, 01.12.1977, p. 771-773.

Research output: Contribution to journalArticle

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