Abstract
The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.
| Original language | English |
|---|---|
| Pages (from-to) | 771-773 |
| Number of pages | 3 |
| Journal | Archives of Neurology |
| Volume | 34 |
| Issue number | 12 |
| State | Published - Dec 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy. / Enomoto, A.; Bradley, Walter G.
In: Archives of Neurology, Vol. 34, No. 12, 01.12.1977, p. 771-773.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy
AU - Enomoto, A.
AU - Bradley, Walter G
PY - 1977/12/1
Y1 - 1977/12/1
N2 - The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.
AB - The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.
UR - http://www.scopus.com/inward/record.url?scp=0017585840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017585840&partnerID=8YFLogxK
M3 - Article
C2 - 337944
AN - SCOPUS:0017585840
VL - 34
SP - 771
EP - 773
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 12
ER -