Therapeutic Trials in Muscular Dystrophy: III. Studies of Microbial Proteinase Inhibitors in Murine Dystrophy

Akira Enomoto, Walter G. Bradley

Research output: Contribution to journalArticle

15 Scopus citations


The microbial antiproteinases - antipain, leupeptin, and pepstatin - have been reported to inhibit the degeneration of chicken dystrophic muscle in tissue culture. Trials of antipain and pepstatin, and of leupeptin and pepstatin administered subcutaneously in murine muscular dystrophy, failed to produce evidence of benefit. It is suggested that these antiproteinases cannot pass through an intact sarcolemma into muscle fibers. Further studies with liposomes may allow these agents to enter muscle fibers.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalArchives of neurology
Issue number12
StatePublished - Dec 1977
Externally publishedYes


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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