Therapeutic trials in muscular dystrophy. I. Gold in murine dystrophy

A. Enomoto; W. G. Bradley

doi:10.1136/jnnp.41.5.404

Therapeutic trials in muscular dystrophy. I. Gold in murine dystrophy

A. Enomoto, W. G. Bradley

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A trial of sodium aurothiomalate as an antiproteinase drug in the treatment of murine muscular dystrophy is reported. A blind controlled comparison of high (25 μg/10 g body weight) and low dose gold (5 μg/10 g body weight) with saline-injected control animals was made, all injections being given 3 times weekly. The body weights and functional ability of the mice were assessed at weekly intervals. No significant difference between the groups was observed. A trial of very high dose chrysotherapy (500 μg of gold/10 g body weight) also showed no therapeutic benefit.

Original language	English (US)
Pages (from-to)	404-407
Number of pages	4
Journal	Journal of Neurology Neurosurgery and Psychiatry
Volume	41
Issue number	5
DOIs	https://doi.org/10.1136/jnnp.41.5.404
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Surgery
Clinical Neurology
Psychiatry and Mental health

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AB - A trial of sodium aurothiomalate as an antiproteinase drug in the treatment of murine muscular dystrophy is reported. A blind controlled comparison of high (25 μg/10 g body weight) and low dose gold (5 μg/10 g body weight) with saline-injected control animals was made, all injections being given 3 times weekly. The body weights and functional ability of the mice were assessed at weekly intervals. No significant difference between the groups was observed. A trial of very high dose chrysotherapy (500 μg of gold/10 g body weight) also showed no therapeutic benefit.

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