Therapeutic strategies in autoimmune disease: Cyclosporin A as a model agent

D. E. Lemley, P. Katz

Research output: Contribution to journalReview article

3 Scopus citations


Cyclosporin A is the derivative of the cyclic undecapeptide which is produced by 2 strains of fungi, Cylindrocapon lucidum Booth and Tolypocladium inflatum Gams. The drug has achieved widespread use in the treatment of organ transplant recipients as a vanguard against rejection, and currently is being evaluated as an immunosuppressive agent for the therapy of primary autoimmune phenomena as well. Its mechanism of action, and application to the treatment of rheumatologic disorders will be discussed.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalIn Vivo
Issue number1
StatePublished - Jan 1 1988


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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