Therapeutic spectrum of interferon-β in ischemic stroke

Madhuri Wanve, Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanta Pravalika, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Pallab Bhattacharya

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-β therapy that may be helpful in improving stroke outcome are also discussed.

Original languageEnglish (US)
Pages (from-to)116-127
Number of pages12
JournalJournal of Neuroscience Research
Volume97
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Anti-inflammatory
  • IFN-β
  • cytokines
  • stroke

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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  • Cite this

    Wanve, M., Kaur, H., Sarmah, D., Saraf, J., Pravalika, K., Vats, K., Kalia, K., Borah, A., Yavagal, D. R., Dave, K. R., & Bhattacharya, P. (2019). Therapeutic spectrum of interferon-β in ischemic stroke. Journal of Neuroscience Research, 97(2), 116-127. https://doi.org/10.1002/jnr.24333