Therapeutic spectrum of interferon-β in ischemic stroke

Madhuri Wanve, Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanta Pravalika, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R Yavagal, Kunjan R Dave, Pallab Bhattacharya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-β therapy that may be helpful in improving stroke outcome are also discussed.

Original languageEnglish (US)
JournalJournal of Neuroscience Research
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Interferons
Stroke
Interferon-beta
Therapeutics
Tissue Plasminogen Activator
Anti-Inflammatory Agents
Cytokines
Morbidity
Equipment and Supplies
Mortality

Keywords

  • Anti-inflammatory
  • cytokines
  • IFN-β
  • stroke

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Wanve, M., Kaur, H., Sarmah, D., Saraf, J., Pravalika, K., Vats, K., ... Bhattacharya, P. (Accepted/In press). Therapeutic spectrum of interferon-β in ischemic stroke. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24333

Therapeutic spectrum of interferon-β in ischemic stroke. / Wanve, Madhuri; Kaur, Harpreet; Sarmah, Deepaneeta; Saraf, Jackson; Pravalika, Kanta; Vats, Kanchan; Kalia, Kiran; Borah, Anupom; Yavagal, Dileep R; Dave, Kunjan R; Bhattacharya, Pallab.

In: Journal of Neuroscience Research, 01.01.2018.

Research output: Contribution to journalArticle

Wanve, M, Kaur, H, Sarmah, D, Saraf, J, Pravalika, K, Vats, K, Kalia, K, Borah, A, Yavagal, DR, Dave, KR & Bhattacharya, P 2018, 'Therapeutic spectrum of interferon-β in ischemic stroke', Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24333
Wanve, Madhuri ; Kaur, Harpreet ; Sarmah, Deepaneeta ; Saraf, Jackson ; Pravalika, Kanta ; Vats, Kanchan ; Kalia, Kiran ; Borah, Anupom ; Yavagal, Dileep R ; Dave, Kunjan R ; Bhattacharya, Pallab. / Therapeutic spectrum of interferon-β in ischemic stroke. In: Journal of Neuroscience Research. 2018.
@article{764ee1eb71ca44fa8861ba4e0e13d994,
title = "Therapeutic spectrum of interferon-β in ischemic stroke",
abstract = "Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-β therapy that may be helpful in improving stroke outcome are also discussed.",
keywords = "Anti-inflammatory, cytokines, IFN-β, stroke",
author = "Madhuri Wanve and Harpreet Kaur and Deepaneeta Sarmah and Jackson Saraf and Kanta Pravalika and Kanchan Vats and Kiran Kalia and Anupom Borah and Yavagal, {Dileep R} and Dave, {Kunjan R} and Pallab Bhattacharya",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/jnr.24333",
language = "English (US)",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Therapeutic spectrum of interferon-β in ischemic stroke

AU - Wanve, Madhuri

AU - Kaur, Harpreet

AU - Sarmah, Deepaneeta

AU - Saraf, Jackson

AU - Pravalika, Kanta

AU - Vats, Kanchan

AU - Kalia, Kiran

AU - Borah, Anupom

AU - Yavagal, Dileep R

AU - Dave, Kunjan R

AU - Bhattacharya, Pallab

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-β therapy that may be helpful in improving stroke outcome are also discussed.

AB - Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-β), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-β may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-β along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-β therapy that may be helpful in improving stroke outcome are also discussed.

KW - Anti-inflammatory

KW - cytokines

KW - IFN-β

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85055059734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055059734&partnerID=8YFLogxK

U2 - 10.1002/jnr.24333

DO - 10.1002/jnr.24333

M3 - Article

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

ER -