Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

Vimal Master Sankar Raj; Amanda Alladin; Brent Pfeiffer; Chryso Katsoufis; Marissa Defreitas; Alicia Edwards-Richards; Jayanthi Chandar; Wacharee Seeherunvong; Gwenn McLaughlin; Gaston Zilleruelo; Carolyn L. Abitbol

doi:10.1007/s00467-013-2409-8

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

Vimal Master Sankar Raj, Amanda Alladin, Brent Pfeiffer, Chryso Katsoufis, Marissa Defreitas, Alicia Edwards-Richards, Jayanthi Chandar, Wacharee Seeherunvong, Gwenn McLaughlin, Gaston Zilleruelo, Carolyn L. Abitbol

Pediatrics

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

Background: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. Case Diagnosis and Treatments: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. Conclusions: The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

Original language	English (US)
Pages (from-to)	971-974
Number of pages	4
Journal	Pediatric Nephrology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1007/s00467-013-2409-8
State	Published - Jun 1 2013

Keywords

Continuous renal replacement therapy
Heat stroke
Therapeutic plasma exchange

ASJC Scopus subject areas

Nephrology
Pediatrics, Perinatology, and Child Health

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Raj, V. M. S., Alladin, A., Pfeiffer, B., Katsoufis, C., Defreitas, M., Edwards-Richards, A., Chandar, J., Seeherunvong, W., McLaughlin, G., Zilleruelo, G., & Abitbol, C. L. (2013). Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. Pediatric Nephrology, 28(6), 971-974. https://doi.org/10.1007/s00467-013-2409-8

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. / Raj, Vimal Master Sankar; Alladin, Amanda; Pfeiffer, Brent ; Katsoufis, Chryso; Defreitas, Marissa; Edwards-Richards, Alicia; Chandar, Jayanthi ; Seeherunvong, Wacharee ; McLaughlin, Gwenn; Zilleruelo, Gaston; Abitbol, Carolyn L.

In: Pediatric Nephrology, Vol. 28, No. 6, 01.06.2013, p. 971-974.

Research output: Contribution to journal › Article

Raj, Vimal Master Sankar ; Alladin, Amanda ; Pfeiffer, Brent ; Katsoufis, Chryso ; Defreitas, Marissa ; Edwards-Richards, Alicia ; Chandar, Jayanthi ; Seeherunvong, Wacharee ; McLaughlin, Gwenn ; Zilleruelo, Gaston ; Abitbol, Carolyn L. / Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. In: Pediatric Nephrology. 2013 ; Vol. 28, No. 6. pp. 971-974.

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