Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

Vimal Master Sankar Raj; Amanda Alladin; Brent Pfeiffer; Chryso Katsoufis; Marissa Defreitas; Alicia Edwards-Richards; Jayanthi Chandar; Wacharee Seeherunvong; Gwenn McLaughlin; Gaston Zilleruelo; Carolyn L. Abitbol

doi:10.1007/s00467-013-2409-8

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

Vimal Master Sankar Raj, Amanda Alladin, Brent Pfeiffer, Chryso Katsoufis, Marissa Defreitas, Alicia Edwards-Richards, Jayanthi Chandar, Wacharee Seeherunvong, Gwenn McLaughlin, Gaston Zilleruelo, Carolyn L. Abitbol

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. Case Diagnosis and Treatments: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. Conclusions: The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

Original language	English (US)
Pages (from-to)	971-974
Number of pages	4
Journal	Pediatric Nephrology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1007/s00467-013-2409-8
State	Published - Jun 1 2013

Keywords

Continuous renal replacement therapy
Heat stroke
Therapeutic plasma exchange

ASJC Scopus subject areas

Nephrology
Pediatrics, Perinatology, and Child Health

Access to Document

10.1007/s00467-013-2409-8

Fingerprint Dive into the research topics of 'Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure'. Together they form a unique fingerprint.

Cite this

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. / Raj, Vimal Master Sankar; Alladin, Amanda; Pfeiffer, Brent ; Katsoufis, Chryso; Defreitas, Marissa; Edwards-Richards, Alicia; Chandar, Jayanthi ; Seeherunvong, Wacharee ; McLaughlin, Gwenn; Zilleruelo, Gaston; Abitbol, Carolyn L.

In: Pediatric Nephrology, Vol. 28, No. 6, 01.06.2013, p. 971-974.

Research output: Contribution to journal › Article › peer-review

Raj, Vimal Master Sankar ; Alladin, Amanda ; Pfeiffer, Brent ; Katsoufis, Chryso ; Defreitas, Marissa ; Edwards-Richards, Alicia ; Chandar, Jayanthi ; Seeherunvong, Wacharee ; McLaughlin, Gwenn ; Zilleruelo, Gaston ; Abitbol, Carolyn L. / Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. In: Pediatric Nephrology. 2013 ; Vol. 28, No. 6. pp. 971-974.

@article{955063e0265d450698acc705b2a5d476,

title = "Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure",

abstract = "Background: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. Case Diagnosis and Treatments: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as {"}extensive hepatocyte ballooning{"} and liver-kidney transplantation was tentatively planned. Conclusions: The addition of therapeutic plasma exchange using the Prismaflex{\textregistered} system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.",

keywords = "Continuous renal replacement therapy, Heat stroke, Therapeutic plasma exchange",

author = "Raj, {Vimal Master Sankar} and Amanda Alladin and Brent Pfeiffer and Chryso Katsoufis and Marissa Defreitas and Alicia Edwards-Richards and Jayanthi Chandar and Wacharee Seeherunvong and Gwenn McLaughlin and Gaston Zilleruelo and Abitbol, {Carolyn L.}",

year = "2013",

month = jun,

day = "1",

doi = "10.1007/s00467-013-2409-8",

language = "English (US)",

volume = "28",

pages = "971--974",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Verlag",

number = "6",

}

TY - JOUR

T1 - Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure

AU - Raj, Vimal Master Sankar

AU - Alladin, Amanda

AU - Pfeiffer, Brent

AU - Katsoufis, Chryso

AU - Defreitas, Marissa

AU - Edwards-Richards, Alicia

AU - Chandar, Jayanthi

AU - Seeherunvong, Wacharee

AU - McLaughlin, Gwenn

AU - Zilleruelo, Gaston

AU - Abitbol, Carolyn L.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. Case Diagnosis and Treatments: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. Conclusions: The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

AB - Background: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. Case Diagnosis and Treatments: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. Conclusions: The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.

KW - Continuous renal replacement therapy

KW - Heat stroke

KW - Therapeutic plasma exchange

UR - http://www.scopus.com/inward/record.url?scp=84880570306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880570306&partnerID=8YFLogxK

U2 - 10.1007/s00467-013-2409-8

DO - 10.1007/s00467-013-2409-8

M3 - Article

C2 - 23338054

AN - SCOPUS:84880570306

VL - 28

SP - 971

EP - 974

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 6

ER -