Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload

Banu Aygun, Nicole A. Mortier, Karen Kesler, Alexandre Lockhart, William H. Schultz, Alan R. Cohen, Ofelia A Alvarez, Zora R. Rogers, Janet L. Kwiatkowski, Scott T. Miller, Pamela Sylvestre, Rathi Iyer, Peter A. Lane, Russell E. Ware

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained unchanged. Therapeutic phlebotomy was safe and well-tolerated, with net iron removal in most children who completed 30 months of protocol-directed treatment.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalBritish Journal of Haematology
Volume169
Issue number2
DOIs
StatePublished - Apr 1 2015

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Keywords

  • Iron overload
  • Liver iron
  • Phlebotomy
  • Sickle cell

ASJC Scopus subject areas

  • Hematology

Cite this

Aygun, B., Mortier, N. A., Kesler, K., Lockhart, A., Schultz, W. H., Cohen, A. R., Alvarez, O. A., Rogers, Z. R., Kwiatkowski, J. L., Miller, S. T., Sylvestre, P., Iyer, R., Lane, P. A., & Ware, R. E. (2015). Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload. British Journal of Haematology, 169(2), 262-266. https://doi.org/10.1111/bjh.13280