Therapeutic options in frontal fibrosing alopecia

Raymond Fertig, Nouf M. Aleid, Tosti Antonella

Research output: Contribution to journalReview articlepeer-review


Introduction: The prevalence of frontal fibrosing alopecia (FFA) is increasing worldwide and early diagnosis and prompt treatment are necessary to prevent definitive scarring. Currently, there are no FDA approved treatments for FFA. This paper seeks to explore the efficacy of current therapeutic options in FFA.Areas covered: The evidence available to date gives some guidance as to potential effective treatment approaches for FFA patients which include 5-alpha-reductase inhibitors, intralesional steroids, hydroxychloroquine, topical calcineurin inhibitors, excimer laser, pioglitazone, oral tetracyclines and minoxidil. A MEDLINE search (PubMed 1994-2015) was performed to identify the cases described in the literature. The MEDLINE search terms Frontal Fibrosing Alopecia and Treatment were used in combination with no language restrictions. We included case reports, case series, review articles and clinical trials which specifically mentioned attempted therapeutic modalities in FFA and their respective outcomes following treatment.Expert opinion: I first reported the efficacy of finasteride in FFA patients 12 years ago and still widely utilize this medication when treating patients with FFA. In treating FFA patients I prefer to associate oral finasteride to topical tacrolimus, hydroxychloroquine and excimer laser in patients with clinical or dermoscopic evidence of active inflammation.

Original languageEnglish (US)
Pages (from-to)461-468
Number of pages8
JournalExpert Opinion on Orphan Drugs
Issue number5
StatePublished - May 3 2016


  • FFA
  • FFA therapy
  • frontal fibrosing alopecia
  • treatment

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Health Policy
  • Pharmacology (medical)


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