Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging

R. A. Potish, L. B. Twiggs, T. Okagaki, K. A. Prem, L. L. Adcock

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five-year actuarial relapse-free survival rates were a strong function of lymphatic spread: 40% with periaortic node metastases, 50% with pelvic node metastases, and 84% without node metastases. Primary treatment failure had a distant component in 75% of recurrences (50% of recurrences with negative nodes and 85% of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.

Original languageEnglish
Pages (from-to)956-960
Number of pages5
JournalCancer
Volume56
Issue number4
DOIs
StatePublished - Nov 28 1985
Externally publishedYes

Fingerprint

Natural History
Uterine Cervical Neoplasms
Recurrence
Neoplasm Metastasis
Therapeutics
Treatment Failure
Radiotherapy
Survival Rate
Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging. / Potish, R. A.; Twiggs, L. B.; Okagaki, T.; Prem, K. A.; Adcock, L. L.

In: Cancer, Vol. 56, No. 4, 28.11.1985, p. 956-960.

Research output: Contribution to journalArticle

Potish, R. A. ; Twiggs, L. B. ; Okagaki, T. ; Prem, K. A. ; Adcock, L. L. / Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging. In: Cancer. 1985 ; Vol. 56, No. 4. pp. 956-960.
@article{e107653bcbb342b2a9f430780e707260,
title = "Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging",
abstract = "From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five-year actuarial relapse-free survival rates were a strong function of lymphatic spread: 40{\%} with periaortic node metastases, 50{\%} with pelvic node metastases, and 84{\%} without node metastases. Primary treatment failure had a distant component in 75{\%} of recurrences (50{\%} of recurrences with negative nodes and 85{\%} of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.",
author = "Potish, {R. A.} and Twiggs, {L. B.} and T. Okagaki and Prem, {K. A.} and Adcock, {L. L.}",
year = "1985",
month = "11",
day = "28",
doi = "10.1002/1097-0142(19850815)56:4<956::AID-CNCR2820560442>3.0.CO;2-U",
language = "English",
volume = "56",
pages = "956--960",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Therapeutic implications of the natural history of advanced cervical cancer as defined by pretreatment surgical staging

AU - Potish, R. A.

AU - Twiggs, L. B.

AU - Okagaki, T.

AU - Prem, K. A.

AU - Adcock, L. L.

PY - 1985/11/28

Y1 - 1985/11/28

N2 - From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five-year actuarial relapse-free survival rates were a strong function of lymphatic spread: 40% with periaortic node metastases, 50% with pelvic node metastases, and 84% without node metastases. Primary treatment failure had a distant component in 75% of recurrences (50% of recurrences with negative nodes and 85% of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.

AB - From 1978 to 1983, 112 women with advanced cervical carcinomas received radiotherapy after pretreatment surgical staging. Five-year actuarial relapse-free survival rates were a strong function of lymphatic spread: 40% with periaortic node metastases, 50% with pelvic node metastases, and 84% without node metastases. Primary treatment failure had a distant component in 75% of recurrences (50% of recurrences with negative nodes and 85% of recurrences with positive nodes). It was concluded that adjuvant systemic therapy is necessary to substantially raise the probability of cure.

UR - http://www.scopus.com/inward/record.url?scp=0021925997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021925997&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19850815)56:4<956::AID-CNCR2820560442>3.0.CO;2-U

DO - 10.1002/1097-0142(19850815)56:4<956::AID-CNCR2820560442>3.0.CO;2-U

M3 - Article

C2 - 4016688

AN - SCOPUS:0021925997

VL - 56

SP - 956

EP - 960

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -