Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in 'spontaneous' and 'transplantable' mammary tumors

Paul G Braunschweiger, L. M. Schiffer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The 3H-thymidine (3H-TdR) labeling index (LI), the DNA synthesis times, and the primer-dependent DNA polymerase labeling index (PDPI) were determined by in vitro methods for spontaneous mammary tumors (SMT) in C3H/HeJ retired breeders and 13762 transplantable rat mammary tumors (RMT) in Fischer 344 rats from 6 hours to 14 days after Cp treatment. The perturbations in the cell kinetics, although quantitatively different in the two tumor models, were qualitatively similar in that transient changes in both PDPI and 3H-TdR LI were observed within the first 24 hours after treatment. These changes were followed by a variable period during which cell proliferation was suppressed. Increases in the PDPI and 3H-TdR LI, presumably reflecting proliferative recovery, were observed prior to the initiation of tumor regrowth. Increases in the 3H-TdR LI and PDPI within the first 24 hours after Cp in C3H/HeJ SMT indicated an interval of increased sensitivity to adriamycin. In the 13762 RMT, combination chemotherapy protocols designed to exploit changes in cell kinetics at early times (24 hours) and during the recovery phase of the response resulted in greater long-term tumor-free survival.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalCancer Treatment Reports
Volume62
Issue number5
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

DNA-Directed DNA Polymerase
Cyclophosphamide
Breast Neoplasms
Neoplasms
Inbred F344 Rats
Therapeutics
Combination Drug Therapy
Doxorubicin
Thymidine
Cell Proliferation
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in 'spontaneous' and 'transplantable' mammary tumors. / Braunschweiger, Paul G; Schiffer, L. M.

In: Cancer Treatment Reports, Vol. 62, No. 5, 01.12.1978, p. 727-736.

Research output: Contribution to journalArticle

@article{652497467bfc4c97a3f0a441f5b3176a,
title = "Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in 'spontaneous' and 'transplantable' mammary tumors",
abstract = "The 3H-thymidine (3H-TdR) labeling index (LI), the DNA synthesis times, and the primer-dependent DNA polymerase labeling index (PDPI) were determined by in vitro methods for spontaneous mammary tumors (SMT) in C3H/HeJ retired breeders and 13762 transplantable rat mammary tumors (RMT) in Fischer 344 rats from 6 hours to 14 days after Cp treatment. The perturbations in the cell kinetics, although quantitatively different in the two tumor models, were qualitatively similar in that transient changes in both PDPI and 3H-TdR LI were observed within the first 24 hours after treatment. These changes were followed by a variable period during which cell proliferation was suppressed. Increases in the PDPI and 3H-TdR LI, presumably reflecting proliferative recovery, were observed prior to the initiation of tumor regrowth. Increases in the 3H-TdR LI and PDPI within the first 24 hours after Cp in C3H/HeJ SMT indicated an interval of increased sensitivity to adriamycin. In the 13762 RMT, combination chemotherapy protocols designed to exploit changes in cell kinetics at early times (24 hours) and during the recovery phase of the response resulted in greater long-term tumor-free survival.",
author = "Braunschweiger, {Paul G} and Schiffer, {L. M.}",
year = "1978",
month = "12",
day = "1",
language = "English",
volume = "62",
pages = "727--736",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in 'spontaneous' and 'transplantable' mammary tumors

AU - Braunschweiger, Paul G

AU - Schiffer, L. M.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - The 3H-thymidine (3H-TdR) labeling index (LI), the DNA synthesis times, and the primer-dependent DNA polymerase labeling index (PDPI) were determined by in vitro methods for spontaneous mammary tumors (SMT) in C3H/HeJ retired breeders and 13762 transplantable rat mammary tumors (RMT) in Fischer 344 rats from 6 hours to 14 days after Cp treatment. The perturbations in the cell kinetics, although quantitatively different in the two tumor models, were qualitatively similar in that transient changes in both PDPI and 3H-TdR LI were observed within the first 24 hours after treatment. These changes were followed by a variable period during which cell proliferation was suppressed. Increases in the PDPI and 3H-TdR LI, presumably reflecting proliferative recovery, were observed prior to the initiation of tumor regrowth. Increases in the 3H-TdR LI and PDPI within the first 24 hours after Cp in C3H/HeJ SMT indicated an interval of increased sensitivity to adriamycin. In the 13762 RMT, combination chemotherapy protocols designed to exploit changes in cell kinetics at early times (24 hours) and during the recovery phase of the response resulted in greater long-term tumor-free survival.

AB - The 3H-thymidine (3H-TdR) labeling index (LI), the DNA synthesis times, and the primer-dependent DNA polymerase labeling index (PDPI) were determined by in vitro methods for spontaneous mammary tumors (SMT) in C3H/HeJ retired breeders and 13762 transplantable rat mammary tumors (RMT) in Fischer 344 rats from 6 hours to 14 days after Cp treatment. The perturbations in the cell kinetics, although quantitatively different in the two tumor models, were qualitatively similar in that transient changes in both PDPI and 3H-TdR LI were observed within the first 24 hours after treatment. These changes were followed by a variable period during which cell proliferation was suppressed. Increases in the PDPI and 3H-TdR LI, presumably reflecting proliferative recovery, were observed prior to the initiation of tumor regrowth. Increases in the 3H-TdR LI and PDPI within the first 24 hours after Cp in C3H/HeJ SMT indicated an interval of increased sensitivity to adriamycin. In the 13762 RMT, combination chemotherapy protocols designed to exploit changes in cell kinetics at early times (24 hours) and during the recovery phase of the response resulted in greater long-term tumor-free survival.

UR - http://www.scopus.com/inward/record.url?scp=0018188514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018188514&partnerID=8YFLogxK

M3 - Article

C2 - 657158

AN - SCOPUS:0018188514

VL - 62

SP - 727

EP - 736

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 5

ER -