Therapeutic hypothermia in spinal cord injury

The status of its use and open questions

Jiaqiong Wang, Damien D Pearse

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is a major health problem and is associated with a diversity of neurological symptoms. Pathophysiologically, dysfunction after SCI results from the culmination of tissue damage produced both by the primary insult and a range of secondary injury mechanisms. The application of hypothermia has been demonstrated to be neuroprotective after SCI in both experimental and human studies. The myriad of protective mechanisms of hypothermia include the slowing down of metabolism, decreasing free radical generation, inhibiting excitotoxicity and apoptosis, ameliorating inflammation, preserving the blood spinal cord barrier, inhibiting astrogliosis, promoting angiogenesis, as well as decreasing axonal damage and encouraging neurogenesis. Hypothermia has also been combined with other interventions, such as antioxidants, anesthetics, alkalinization and cell transplantation for additional benefit. Although a large body of work has reported on the effectiveness of hypothermia as a neuroprotective approach after SCI and its application has been translated to the clinic, a number of questions still remain regarding its use, including the identification of hypothermia’s therapeutic window, optimal duration and the most appropriate rewarming rate. In addition, it is necessary to investigate the neuroprotective effect of combining therapeutic hypothermia with other treatment strategies for putative synergies, particularly those involving neurorepair.

Original languageEnglish (US)
Pages (from-to)16848-16879
Number of pages32
JournalInternational Journal of Molecular Sciences
Volume16
Issue number8
DOIs
StatePublished - Jul 24 2015

Fingerprint

hypothermia
spinal cord injuries
Hypothermia
Induced Hypothermia
Spinal Cord Injuries
Rewarming
Cell Transplantation
Neurogenesis
damage
Neuroprotective Agents
anesthetics
angiogenesis
transplantation
Anesthetics
spinal cord
Free Radicals
antioxidants
apoptosis
metabolism
Cell death

Keywords

  • Angiogenesis
  • Cell death
  • Cooling
  • Free radicals
  • Hypothermia
  • Inflammation
  • Neuroprotectivion
  • Spinal cord injury
  • Transplantation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Therapeutic hypothermia in spinal cord injury : The status of its use and open questions. / Wang, Jiaqiong; Pearse, Damien D.

In: International Journal of Molecular Sciences, Vol. 16, No. 8, 24.07.2015, p. 16848-16879.

Research output: Contribution to journalArticle

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