Therapeutic hypothermia for spinal cord injury

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In this article, the role of modest hypothermia for the treatment of experimental and clinical spinal cord injury (SCI) is discussed. While early investigations evaluated the beneficial effects of more profound levels of local hypothermia treatment following SCI, recent studies have concentrated on the benefits of mild hypothermia in protecting and promoting functional recovery in established animal models. In this regard, using preclinical models of both thoracic and cervical contusive SCI, early cooling strategies using systemically administered mild hypothermia (33°C) have been reported to improve locomotive function as well as forelimb gripping strength and coordination. Recently, the effects of modest hypothermia in severely injured SCI patients have also been tested. Modest systemic hypothermia was reported to be both safe and achievable in severely injured SCI patients. This evidence-based review summarizes both experimental and clinical data to support the use of modest hypothermia in the acute SCI setting.

Original languageEnglish
JournalCritical Care Medicine
Volume37
Issue numberSUPPL. 7
DOIs
StatePublished - Jul 1 2009

Fingerprint

Induced Hypothermia
Hypothermia
Spinal Cord Injuries
Forelimb
Thorax
Animal Models
Therapeutics

Keywords

  • Clinical trials
  • Hyperthermia
  • Hypothermia
  • Pathomechanisms
  • Rewarming phase
  • Spinal cord injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Therapeutic hypothermia for spinal cord injury. / Dalton Dietrich, W.

In: Critical Care Medicine, Vol. 37, No. SUPPL. 7, 01.07.2009.

Research output: Contribution to journalArticle

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