Therapeutic effect of transcatheter arterial chemoembolization on hepatocellular carcinoma: Evaluation with contrast-enhanced harmonic power Doppler ultrasound

D. Cioni, R. Lencioni, C. Bartolozzi

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The aim of this study was to investigate the usefulness of contrast-enhanced harmonic power Doppler ultrasound (US) for the detection of residual viable hepatocellular carcinoma (HCC) after treatment with transcatheter arterial chemoembolization (TACE). Forty-seven patients with 68 HCC lesions 1.8-9.5 cm in diameter (mean ± SD 4.3 ± 1.7 cm) underwent contrast-enhanced power Doppler US, in the harmonic mode, before and after treatment with TACE. Unenhanced spiral CT and contrast-enhanced dynamic MR imaging were also performed to help establish the outcome of therapy. Before treatment, intratumoral blood flow signals were detected at contrast-enhanced harmonic power Doppler US in 65 (95%) of 68 lesions. After TACE, flow signals were no longer detectable in 22 of these 65 lesions, which showed complete response at spiral CT and dynamic MR imaging. In 38 (88%) of the 43 lesions with partial response, intratumoral flow signals were still identified at contrast-enhanced harmonic power Doppler US. Twenty-eight of these 38 lesions underwent additional treatment with percutaneous ethanol injection (PEI) using contrast-enhanced harmonic power Doppler US guidance. Complete response was seen after PEI in 23 of 28 lesions. Contrast-enhanced harmonic power Doppler US proved useful for assessing the therapeutic effect of TACE on HCC and for guiding additional treatment with PEI in cases of partial response.

Original languageEnglish (US)
Pages (from-to)1570-1575
Number of pages6
JournalEuropean Radiology
Volume10
Issue number10
DOIs
StatePublished - Jan 1 2000

Keywords

  • Contrast media
  • Interventional procedure
  • Liver
  • Neoplasms
  • US
  • US Doppler studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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