Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia

A. Zarate, F. Valdes Vallina, A. Gonzalez, F. Valdés-Vallina, C. Pérez-Ubierna, E. S. Canales, Andrew V Schally

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The demonstration that synthetic LHRH stimulates the release of gonadotropins and subsequent ovulation in certain anovulatory women suggested that this hormone could be tried in infertile men with idiopathic oligospermia and azoospermia. 10 males between the ages of 25 and 35 year were administered LHRH, 500 μg. twice a day, intramuscularly, during 6 month. Three out of the 4 azoospermic patients showed an increase in the sperm count after therapy but the highest increase was below 6 million/ml.; the remaining azoospermic male had an increase up to 0.5 million/ml. In the group of 6 oligospermic patients, 3 had more than 20 million/ml. after 3 mth of therapy, but the sperm count decreased in spite of the continued administration of LH RH, and the 3 remaining patients showed only mild variations in the sperm count. Mobility and normal forms increased in all cases regardless of the total count per milliliter. No pregnancies in the wives of these patients were observed. Although these results are disappointing, it is possible that different treatment modalities would yield more positive effects.

Original languageEnglish
Pages (from-to)485-486
Number of pages2
JournalFertility and Sterility
Volume24
Issue number6
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint

Oligospermia
Azoospermia
Male Infertility
Therapeutic Uses
Gonadotropin-Releasing Hormone
Sperm Count
Ovulation
Gonadotropins
Spouses
Therapeutics
Hormones
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Zarate, A., Valdes Vallina, F., Gonzalez, A., Valdés-Vallina, F., Pérez-Ubierna, C., Canales, E. S., & Schally, A. V. (1973). Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. Fertility and Sterility, 24(6), 485-486.

Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. / Zarate, A.; Valdes Vallina, F.; Gonzalez, A.; Valdés-Vallina, F.; Pérez-Ubierna, C.; Canales, E. S.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 24, No. 6, 01.12.1973, p. 485-486.

Research output: Contribution to journalArticle

Zarate, A, Valdes Vallina, F, Gonzalez, A, Valdés-Vallina, F, Pérez-Ubierna, C, Canales, ES & Schally, AV 1973, 'Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia', Fertility and Sterility, vol. 24, no. 6, pp. 485-486.
Zarate A, Valdes Vallina F, Gonzalez A, Valdés-Vallina F, Pérez-Ubierna C, Canales ES et al. Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. Fertility and Sterility. 1973 Dec 1;24(6):485-486.
Zarate, A. ; Valdes Vallina, F. ; Gonzalez, A. ; Valdés-Vallina, F. ; Pérez-Ubierna, C. ; Canales, E. S. ; Schally, Andrew V. / Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. In: Fertility and Sterility. 1973 ; Vol. 24, No. 6. pp. 485-486.
@article{7d0047d831ba47d5b89ff39f2e8226cb,
title = "Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia",
abstract = "The demonstration that synthetic LHRH stimulates the release of gonadotropins and subsequent ovulation in certain anovulatory women suggested that this hormone could be tried in infertile men with idiopathic oligospermia and azoospermia. 10 males between the ages of 25 and 35 year were administered LHRH, 500 μg. twice a day, intramuscularly, during 6 month. Three out of the 4 azoospermic patients showed an increase in the sperm count after therapy but the highest increase was below 6 million/ml.; the remaining azoospermic male had an increase up to 0.5 million/ml. In the group of 6 oligospermic patients, 3 had more than 20 million/ml. after 3 mth of therapy, but the sperm count decreased in spite of the continued administration of LH RH, and the 3 remaining patients showed only mild variations in the sperm count. Mobility and normal forms increased in all cases regardless of the total count per milliliter. No pregnancies in the wives of these patients were observed. Although these results are disappointing, it is possible that different treatment modalities would yield more positive effects.",
author = "A. Zarate and {Valdes Vallina}, F. and A. Gonzalez and F. Vald{\'e}s-Vallina and C. P{\'e}rez-Ubierna and Canales, {E. S.} and Schally, {Andrew V}",
year = "1973",
month = "12",
day = "1",
language = "English",
volume = "24",
pages = "485--486",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia

AU - Zarate, A.

AU - Valdes Vallina, F.

AU - Gonzalez, A.

AU - Valdés-Vallina, F.

AU - Pérez-Ubierna, C.

AU - Canales, E. S.

AU - Schally, Andrew V

PY - 1973/12/1

Y1 - 1973/12/1

N2 - The demonstration that synthetic LHRH stimulates the release of gonadotropins and subsequent ovulation in certain anovulatory women suggested that this hormone could be tried in infertile men with idiopathic oligospermia and azoospermia. 10 males between the ages of 25 and 35 year were administered LHRH, 500 μg. twice a day, intramuscularly, during 6 month. Three out of the 4 azoospermic patients showed an increase in the sperm count after therapy but the highest increase was below 6 million/ml.; the remaining azoospermic male had an increase up to 0.5 million/ml. In the group of 6 oligospermic patients, 3 had more than 20 million/ml. after 3 mth of therapy, but the sperm count decreased in spite of the continued administration of LH RH, and the 3 remaining patients showed only mild variations in the sperm count. Mobility and normal forms increased in all cases regardless of the total count per milliliter. No pregnancies in the wives of these patients were observed. Although these results are disappointing, it is possible that different treatment modalities would yield more positive effects.

AB - The demonstration that synthetic LHRH stimulates the release of gonadotropins and subsequent ovulation in certain anovulatory women suggested that this hormone could be tried in infertile men with idiopathic oligospermia and azoospermia. 10 males between the ages of 25 and 35 year were administered LHRH, 500 μg. twice a day, intramuscularly, during 6 month. Three out of the 4 azoospermic patients showed an increase in the sperm count after therapy but the highest increase was below 6 million/ml.; the remaining azoospermic male had an increase up to 0.5 million/ml. In the group of 6 oligospermic patients, 3 had more than 20 million/ml. after 3 mth of therapy, but the sperm count decreased in spite of the continued administration of LH RH, and the 3 remaining patients showed only mild variations in the sperm count. Mobility and normal forms increased in all cases regardless of the total count per milliliter. No pregnancies in the wives of these patients were observed. Although these results are disappointing, it is possible that different treatment modalities would yield more positive effects.

UR - http://www.scopus.com/inward/record.url?scp=0015839329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015839329&partnerID=8YFLogxK

M3 - Article

C2 - 4575636

AN - SCOPUS:0015839329

VL - 24

SP - 485

EP - 486

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -