Therapeutic effect of synthetic luteinizing hormone releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia

A. Zarate, F. Valdes Vallina, A. Gonzalez, F. Valdés-Vallina, C. Pérez-Ubierna, E. S. Canales, A. V. Schally

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The demonstration that synthetic LHRH stimulates the release of gonadotropins and subsequent ovulation in certain anovulatory women suggested that this hormone could be tried in infertile men with idiopathic oligospermia and azoospermia. 10 males between the ages of 25 and 35 year were administered LHRH, 500 μg. twice a day, intramuscularly, during 6 month. Three out of the 4 azoospermic patients showed an increase in the sperm count after therapy but the highest increase was below 6 million/ml.; the remaining azoospermic male had an increase up to 0.5 million/ml. In the group of 6 oligospermic patients, 3 had more than 20 million/ml. after 3 mth of therapy, but the sperm count decreased in spite of the continued administration of LH RH, and the 3 remaining patients showed only mild variations in the sperm count. Mobility and normal forms increased in all cases regardless of the total count per milliliter. No pregnancies in the wives of these patients were observed. Although these results are disappointing, it is possible that different treatment modalities would yield more positive effects.

Original languageEnglish (US)
Pages (from-to)485-486
Number of pages2
JournalUnknown Journal
Volume24
Issue number6
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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