Abstract
Therapeutic drug monitoring (TDM) is defined as the strategy by which the dosing regimen for a patient is guided by repeated measurements of plasma or serum drug concentrations. TDM is also used to confirm drug poisoning and toxicity, to diagnose adverse drug reactions, and to verify patient compliance with drug regimens. There is a scarcity of data about the use of TDM in treating the elderly, but general inferences can be made based on pharmacokinetic and pharmacodynamic studies in older populations and on investigations in younger individuals. Despite its important limitations TDM seems to be an important tool in drug therapy management in the elderly given the increased frequency of chronic medical conditions, polypharmacy, drug interactions, and the atypical presentation of adverse drug reactions in this population.
| Original language | English |
|---|---|
| Pages (from-to) | 839-860 |
| Number of pages | 22 |
| Journal | American Journal of Therapeutics |
| Volume | 3 |
| Issue number | 12 |
| State | Published - Dec 1 1996 |
| Externally published | Yes |
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Keywords
- geropharmacology
- pharmacodynamics
- pharmacokinetics
- therapeutic drug monitoring
ASJC Scopus subject areas
- Pharmacology
Cite this
Therapeutic drug monitoring in the elderly. / Ruiz, Jorge G.; Array, Samir; Lowenthal, David T.
In: American Journal of Therapeutics, Vol. 3, No. 12, 01.12.1996, p. 839-860.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic drug monitoring in the elderly
AU - Ruiz, Jorge G.
AU - Array, Samir
AU - Lowenthal, David T.
PY - 1996/12/1
Y1 - 1996/12/1
N2 - Therapeutic drug monitoring (TDM) is defined as the strategy by which the dosing regimen for a patient is guided by repeated measurements of plasma or serum drug concentrations. TDM is also used to confirm drug poisoning and toxicity, to diagnose adverse drug reactions, and to verify patient compliance with drug regimens. There is a scarcity of data about the use of TDM in treating the elderly, but general inferences can be made based on pharmacokinetic and pharmacodynamic studies in older populations and on investigations in younger individuals. Despite its important limitations TDM seems to be an important tool in drug therapy management in the elderly given the increased frequency of chronic medical conditions, polypharmacy, drug interactions, and the atypical presentation of adverse drug reactions in this population.
AB - Therapeutic drug monitoring (TDM) is defined as the strategy by which the dosing regimen for a patient is guided by repeated measurements of plasma or serum drug concentrations. TDM is also used to confirm drug poisoning and toxicity, to diagnose adverse drug reactions, and to verify patient compliance with drug regimens. There is a scarcity of data about the use of TDM in treating the elderly, but general inferences can be made based on pharmacokinetic and pharmacodynamic studies in older populations and on investigations in younger individuals. Despite its important limitations TDM seems to be an important tool in drug therapy management in the elderly given the increased frequency of chronic medical conditions, polypharmacy, drug interactions, and the atypical presentation of adverse drug reactions in this population.
KW - geropharmacology
KW - pharmacodynamics
KW - pharmacokinetics
KW - therapeutic drug monitoring
UR - http://www.scopus.com/inward/record.url?scp=0030427448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030427448&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030427448
VL - 3
SP - 839
EP - 860
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
SN - 1075-2765
IS - 12
ER -