Therapeutic cloning applications for organ transplantation

Chester J. Koh, Anthony Atala

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalTransplant Immunology
Volume12
Issue number3-4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Fingerprint

Organ Transplantation
Organism Cloning
Tissue Engineering
Tissue Donors
Cell Engineering
Pluripotent Stem Cells
Cell Transplantation
Therapeutics
Embryonic Stem Cells
Oocytes
Technology

Keywords

  • Embryonic stem cells
  • Kidney
  • Regenerative medicine
  • Therapeutic cloning
  • Tissue engineering
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Transplantation

Cite this

Therapeutic cloning applications for organ transplantation. / Koh, Chester J.; Atala, Anthony.

In: Transplant Immunology, Vol. 12, No. 3-4, 01.04.2004, p. 193-201.

Research output: Contribution to journalArticle

Koh, Chester J. ; Atala, Anthony. / Therapeutic cloning applications for organ transplantation. In: Transplant Immunology. 2004 ; Vol. 12, No. 3-4. pp. 193-201.
@article{1ae5567800df43c4a57994dd7caf2fc3,
title = "Therapeutic cloning applications for organ transplantation",
abstract = "A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.",
keywords = "Embryonic stem cells, Kidney, Regenerative medicine, Therapeutic cloning, Tissue engineering, Transplantation",
author = "Koh, {Chester J.} and Anthony Atala",
year = "2004",
month = "4",
day = "1",
doi = "10.1016/j.trim.2003.12.006",
language = "English",
volume = "12",
pages = "193--201",
journal = "Transplant Immunology",
issn = "0966-3274",
publisher = "Elsevier",
number = "3-4",

}

TY - JOUR

T1 - Therapeutic cloning applications for organ transplantation

AU - Koh, Chester J.

AU - Atala, Anthony

PY - 2004/4/1

Y1 - 2004/4/1

N2 - A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

AB - A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

KW - Embryonic stem cells

KW - Kidney

KW - Regenerative medicine

KW - Therapeutic cloning

KW - Tissue engineering

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=2442431585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442431585&partnerID=8YFLogxK

U2 - 10.1016/j.trim.2003.12.006

DO - 10.1016/j.trim.2003.12.006

M3 - Article

C2 - 15157913

AN - SCOPUS:2442431585

VL - 12

SP - 193

EP - 201

JO - Transplant Immunology

JF - Transplant Immunology

SN - 0966-3274

IS - 3-4

ER -