Therapeutic cloning applications for organ transplantation

Chester J. Koh, Anthony Atala

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalTransplant Immunology
Volume12
Issue number3-4
DOIs
StatePublished - Apr 2004

Keywords

  • Embryonic stem cells
  • Kidney
  • Regenerative medicine
  • Therapeutic cloning
  • Tissue engineering
  • Transplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Transplantation

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