Abstract
Our previous in vivo experimental results have shown RPES can enhance skin wound healing by using conforming electrodes. Based on an equation of polarization transmembrane voltage, two equations were derived to describe the peak RPES intensity on skin cells in vivo: (1) U = 1.5 a J/σ, (2) J(m) = 1.5 a (J/σ) (C(m)/τ). Where U: polarization transmembrane voltage. a: radius (R) for spherical cells or semi-length (L) for long fibers parallel to the electrical field. J: external imposed pulse current density under the electrode. σ: average conductivity of skin tissue. J(m): transmembrane displacement current density. C(m): membrane capacitance per unit area and τ: time constant. Calculations indicated that the sensory fibers (SF) would receive the strongest stimulation compared to other cells in skin since generally LSF ≥ 100 R. The sensitivity of SF to the stimulation could enhance skin wound healing as well as protect normal skin cells from harmful electroporation. From these theoretical calculations, we proposed a theoretical range of the pulse current density as: U1 σ/(1.5 L) ≤ J ≤ U2 σ/(1.5 L), where U1 and U2 are the excitation threshold voltage (about 0.01 V) and polarization electroporation voltage (about 0.1 V) for a SF respectively, for RPES to enhance skin wound healing.
Original language | English (US) |
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Title of host publication | Biomedical Sciences Instrumentation |
Publisher | Publ by ISA Services Inc |
Pages | 349-354 |
Number of pages | 6 |
Volume | 29 |
ISBN (Print) | 1556174578 |
State | Published - Jan 1 1993 |
Event | Proceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium - San Antonio, TX, USA Duration: Apr 2 1993 → Apr 3 1993 |
Other
Other | Proceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium |
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City | San Antonio, TX, USA |
Period | 4/2/93 → 4/3/93 |
Keywords
- Conforming electrodes
- RPES
- Sensory fiber(SF)
- Skin wound healing
- Uniform field
ASJC Scopus subject areas
- Hardware and Architecture