Theoretical study of rectangular pulse electrical stimulation(RPES) on skin cells (in vivo) under conforming electrodes

K. Cheng, P. P. Tarjan, P. M. Mertz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Our previous in vivo experimental results have shown RPES can enhance skin wound healing by using conforming electrodes. Based on an equation of polarization transmembrane voltage, two equations were derived to describe the peak RPES intensity on skin cells in vivo: (1) U = 1.5 a J/σ, (2) J(m) = 1.5 a (J/σ) (C(m)/τ). Where U: polarization transmembrane voltage. a: radius (R) for spherical cells or semi-length (L) for long fibers parallel to the electrical field. J: external imposed pulse current density under the electrode. σ: average conductivity of skin tissue. J(m): transmembrane displacement current density. C(m): membrane capacitance per unit area and τ: time constant. Calculations indicated that the sensory fibers (SF) would receive the strongest stimulation compared to other cells in skin since generally LSF ≥ 100 R. The sensitivity of SF to the stimulation could enhance skin wound healing as well as protect normal skin cells from harmful electroporation. From these theoretical calculations, we proposed a theoretical range of the pulse current density as: U1 σ/(1.5 L) ≤ J ≤ U2 σ/(1.5 L), where U1 and U2 are the excitation threshold voltage (about 0.01 V) and polarization electroporation voltage (about 0.1 V) for a SF respectively, for RPES to enhance skin wound healing.

Original languageEnglish (US)
Title of host publicationBiomedical Sciences Instrumentation
PublisherPubl by ISA Services Inc
Pages349-354
Number of pages6
Volume29
ISBN (Print)1556174578
StatePublished - Jan 1 1993
EventProceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium - San Antonio, TX, USA
Duration: Apr 2 1993Apr 3 1993

Other

OtherProceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium
CitySan Antonio, TX, USA
Period4/2/934/3/93

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Keywords

  • Conforming electrodes
  • RPES
  • Sensory fiber(SF)
  • Skin wound healing
  • Uniform field

ASJC Scopus subject areas

  • Hardware and Architecture

Cite this

Cheng, K., Tarjan, P. P., & Mertz, P. M. (1993). Theoretical study of rectangular pulse electrical stimulation(RPES) on skin cells (in vivo) under conforming electrodes. In Biomedical Sciences Instrumentation (Vol. 29, pp. 349-354). Publ by ISA Services Inc.