Abstract
Our previous in vivo experimental results have shown RPES can enhance skin wound healing by using conforming electrodes. Based on an equation of polarization transmembrane voltage, two equations were derived to describe the peak RPES intensity on skin cells in vivo: (1) U = 1.5 a J/σ, (2) J(m) = 1.5 a (J/σ) (C(m)/τ). Where U: polarization transmembrane voltage. a: radius (R) for spherical cells or semi-length (L) for long fibers parallel to the electrical field. J: external imposed pulse current density under the electrode. σ: average conductivity of skin tissue. J(m): transmembrane displacement current density. C(m): membrane capacitance per unit area and τ: time constant. Calculations indicated that the sensory fibers (SF) would receive the strongest stimulation compared to other cells in skin since generally LSF ≥ 100 R. The sensitivity of SF to the stimulation could enhance skin wound healing as well as protect normal skin cells from harmful electroporation. From these theoretical calculations, we proposed a theoretical range of the pulse current density as: U1 σ/(1.5 L) ≤ J ≤ U2 σ/(1.5 L), where U1 and U2 are the excitation threshold voltage (about 0.01 V) and polarization electroporation voltage (about 0.1 V) for a SF respectively, for RPES to enhance skin wound healing.
| Original language | English |
|---|---|
| Title of host publication | Biomedical Sciences Instrumentation |
| Place of Publication | Research Triangle Pk, NC, United States |
| Publisher | Publ by ISA Services Inc |
| Pages | 349-354 |
| Number of pages | 6 |
| Volume | 29 |
| ISBN (Print) | 1556174578 |
| State | Published - Jan 1 1993 |
| Event | Proceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium - San Antonio, TX, USA Duration: Apr 2 1993 → Apr 3 1993 |
Other
| Other | Proceedings of the 30th Annual Rocky Mountain Bioengineering Symposium and the 30th International ISA Biomedical Sciences Instrumentation Symposium |
|---|---|
| City | San Antonio, TX, USA |
| Period | 4/2/93 → 4/3/93 |
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Keywords
- Conforming electrodes
- RPES
- Sensory fiber(SF)
- Skin wound healing
- Uniform field
ASJC Scopus subject areas
- Hardware and Architecture
Cite this
Theoretical study of rectangular pulse electrical stimulation(RPES) on skin cells (in vivo) under conforming electrodes. / Cheng, K.; Tarjan, P. P.; Mertz, P. M.
Biomedical Sciences Instrumentation. Vol. 29 Research Triangle Pk, NC, United States : Publ by ISA Services Inc, 1993. p. 349-354.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Theoretical study of rectangular pulse electrical stimulation(RPES) on skin cells (in vivo) under conforming electrodes
AU - Cheng, K.
AU - Tarjan, P. P.
AU - Mertz, P. M.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Our previous in vivo experimental results have shown RPES can enhance skin wound healing by using conforming electrodes. Based on an equation of polarization transmembrane voltage, two equations were derived to describe the peak RPES intensity on skin cells in vivo: (1) U = 1.5 a J/σ, (2) J(m) = 1.5 a (J/σ) (C(m)/τ). Where U: polarization transmembrane voltage. a: radius (R) for spherical cells or semi-length (L) for long fibers parallel to the electrical field. J: external imposed pulse current density under the electrode. σ: average conductivity of skin tissue. J(m): transmembrane displacement current density. C(m): membrane capacitance per unit area and τ: time constant. Calculations indicated that the sensory fibers (SF) would receive the strongest stimulation compared to other cells in skin since generally LSF ≥ 100 R. The sensitivity of SF to the stimulation could enhance skin wound healing as well as protect normal skin cells from harmful electroporation. From these theoretical calculations, we proposed a theoretical range of the pulse current density as: U1 σ/(1.5 L) ≤ J ≤ U2 σ/(1.5 L), where U1 and U2 are the excitation threshold voltage (about 0.01 V) and polarization electroporation voltage (about 0.1 V) for a SF respectively, for RPES to enhance skin wound healing.
AB - Our previous in vivo experimental results have shown RPES can enhance skin wound healing by using conforming electrodes. Based on an equation of polarization transmembrane voltage, two equations were derived to describe the peak RPES intensity on skin cells in vivo: (1) U = 1.5 a J/σ, (2) J(m) = 1.5 a (J/σ) (C(m)/τ). Where U: polarization transmembrane voltage. a: radius (R) for spherical cells or semi-length (L) for long fibers parallel to the electrical field. J: external imposed pulse current density under the electrode. σ: average conductivity of skin tissue. J(m): transmembrane displacement current density. C(m): membrane capacitance per unit area and τ: time constant. Calculations indicated that the sensory fibers (SF) would receive the strongest stimulation compared to other cells in skin since generally LSF ≥ 100 R. The sensitivity of SF to the stimulation could enhance skin wound healing as well as protect normal skin cells from harmful electroporation. From these theoretical calculations, we proposed a theoretical range of the pulse current density as: U1 σ/(1.5 L) ≤ J ≤ U2 σ/(1.5 L), where U1 and U2 are the excitation threshold voltage (about 0.01 V) and polarization electroporation voltage (about 0.1 V) for a SF respectively, for RPES to enhance skin wound healing.
KW - Conforming electrodes
KW - RPES
KW - Sensory fiber(SF)
KW - Skin wound healing
KW - Uniform field
UR - http://www.scopus.com/inward/record.url?scp=0027305443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027305443&partnerID=8YFLogxK
M3 - Conference contribution
C2 - 8329612
AN - SCOPUS:0027305443
SN - 1556174578
VL - 29
SP - 349
EP - 354
BT - Biomedical Sciences Instrumentation
PB - Publ by ISA Services Inc
CY - Research Triangle Pk, NC, United States
ER -