Abstract
A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 37-38 |
| Number of pages | 2 |
| Journal | Psychonomic Science |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1970 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Morgan, L. L., Schneiderman, N., & Nyhan, W. L. (1970). Theophylline: Induction of self-biting in rabbits. Psychonomic Science, 19(1), 37-38. https://doi.org/10.3758/BF03335496