Theophylline: Induction of self-biting in rabbits

Laura L. Morgan; Neil Schneiderman; William L. Nyhan

doi:10.3758/BF03335496

Theophylline: Induction of self-biting in rabbits

Laura L. Morgan, Neil Schneiderman, William L. Nyhan

Psychology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.

Original language	English (US)
Pages (from-to)	37-38
Number of pages	2
Journal	Psychonomic Science
Volume	19
Issue number	1
DOIs	https://doi.org/10.3758/BF03335496
State	Published - Jul 1970

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.3758/BF03335496

Cite this

@article{42fdff8d8e584b8c954e1815366d82ab,

title = "Theophylline: Induction of self-biting in rabbits",

abstract = "A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.",

author = "Morgan, {Laura L.} and Neil Schneiderman and Nyhan, {William L.}",

year = "1970",

month = jul,

doi = "10.3758/BF03335496",

language = "English (US)",

volume = "19",

pages = "37--38",

journal = "Psychonomic Science",

issn = "0033-3131",

publisher = "Psychonomic Society Inc.",

number = "1",

}

TY - JOUR

T1 - Theophylline

T2 - Induction of self-biting in rabbits

AU - Morgan, Laura L.

AU - Schneiderman, Neil

AU - Nyhan, William L.

PY - 1970/7

Y1 - 1970/7

N2 - A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.

AB - A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.

UR - http://www.scopus.com/inward/record.url?scp=0010011071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0010011071&partnerID=8YFLogxK

U2 - 10.3758/BF03335496

DO - 10.3758/BF03335496

M3 - Article

AN - SCOPUS:0010011071

VL - 19

SP - 37

EP - 38

JO - Psychonomic Science

JF - Psychonomic Science

SN - 0033-3131

IS - 1

ER -

Theophylline: Induction of self-biting in rabbits

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this