Theophylline: Induction of self-biting in rabbits

Laura L. Morgan, Neil Schneiderman, William L. Nyhan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.

Original languageEnglish (US)
Pages (from-to)37-38
Number of pages2
JournalPsychonomic Science
Issue number1
StatePublished - Jul 1970

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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