Theophylline: Induction of self-biting in rabbits

Laura L. Morgan; Neil Schneiderman; William L. Nyhan

doi:10.3758/BF03335496

Theophylline: Induction of self-biting in rabbits

Laura L. Morgan, Neil Schneiderman, William L. Nyhan

Psychology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.

Original language	English (US)
Pages (from-to)	37-38
Number of pages	2
Journal	Psychonomic Science
Volume	19
Issue number	1
DOIs	https://doi.org/10.3758/BF03335496
State	Published - Jul 1970

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Catalysis
Chemistry(all)

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Theophylline: Induction of self-biting in rabbits

Abstract

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