The Yin Yang Role of Nitric Oxide in Prostate Cancer

Yash Soni, Kenneth Softness, Himanshu Arora, Ranjith Ramasamy

Research output: Contribution to journalReview article

Abstract

Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known roles in many different processes and organ systems. In cancer, the two-concentrations hypothesis of NO has dictated that low levels of NO are cancer promoting, while high levels of NO are protective against cancer. Although prostate cancer is a hormonally driven malignancy, research has been shifting away from androgen-responsive epithelial cells and evolving to focus on NO therapies, the tumor microenvironment (TME), and inflammation. NO is reported to be able to inhibit activity of the androgen receptor. This may prevent prostate growth, but low levels of NO could conversely select for castration-resistant prostate cells, creating an aggressive cancer phenotype. At high levels, nitrosative stress created from NO overproduction can be protective against prostate neoplasia. In this review, we discuss development and possibilities of NO-based therapies for prostate cancer.

Original languageEnglish (US)
JournalAmerican Journal of Men's Health
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • CRPC
  • nitric oxide
  • NO and cancer

ASJC Scopus subject areas

  • Health(social science)
  • Public Health, Environmental and Occupational Health

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