The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline

Jing Yang, Tristan Aguero, Mary Lou L King

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

In Xenopus, the germline is specified by the inheritance of germ-plasm components synthesized at the beginning of oogenesis. Only the cells in the early embryo that receive germ plasm, the primordial germ cells (PGCs), are competent to give rise to the gametes. Thus, germ-plasm components continue the totipotent potential exhibited by the oocyte into the developing embryo at a time when most cells are preprogrammed for somatic differentiation as dictated by localized maternal determinants. When zygotic transcription begins at the mid-blastula transition, the maternally set program for somatic differentiation is realized. At this time, genetic control is ceded to the zygotic genome, and developmental potential gradually becomes more restricted within the primary germ layers. PGCs are a notable exception to this paradigm and remain transcriptionally silent until the late gastrula. How the germ-cell lineage retains full potential while somatic cells become fate restricted is a tale of translational repression, selective degradation of somatic maternal determinants, and delayed activation of zygotic transcription.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages271-303
Number of pages33
Volume113
ISBN (Print)9780124095236
DOIs
StatePublished - 2015

Publication series

NameCurrent Topics in Developmental Biology
Volume113
ISSN (Print)00702153

Fingerprint

Xenopus
Germ Cells
Mothers
Embryonic Structures
Blastula
Gastrula
Germ Layers
Oogenesis
Cell Lineage
Transcriptional Activation
Oocytes
Genome

Keywords

  • Germ plasm
  • Mid-blastula transition
  • Primordial germ cells
  • Pumilio
  • Xenopus

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Yang, J., Aguero, T., & King, M. L. L. (2015). The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline. In Current Topics in Developmental Biology (Vol. 113, pp. 271-303). (Current Topics in Developmental Biology; Vol. 113). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2015.07.021

The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline. / Yang, Jing; Aguero, Tristan; King, Mary Lou L.

Current Topics in Developmental Biology. Vol. 113 Academic Press Inc., 2015. p. 271-303 (Current Topics in Developmental Biology; Vol. 113).

Research output: Chapter in Book/Report/Conference proceedingChapter

Yang, J, Aguero, T & King, MLL 2015, The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline. in Current Topics in Developmental Biology. vol. 113, Current Topics in Developmental Biology, vol. 113, Academic Press Inc., pp. 271-303. https://doi.org/10.1016/bs.ctdb.2015.07.021
Yang J, Aguero T, King MLL. The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline. In Current Topics in Developmental Biology. Vol. 113. Academic Press Inc. 2015. p. 271-303. (Current Topics in Developmental Biology). https://doi.org/10.1016/bs.ctdb.2015.07.021
Yang, Jing ; Aguero, Tristan ; King, Mary Lou L. / The Xenopus Maternal-to-Zygotic Transition from the Perspective of the Germline. Current Topics in Developmental Biology. Vol. 113 Academic Press Inc., 2015. pp. 271-303 (Current Topics in Developmental Biology).
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