The wound healing process

Robert Kirsner, W. H. Eaglstein

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

The field of wound repair continues to grow at an astounding pace. In this review we have discussed both the basic science and the clinical aspects of wound healing. The basic science section details the three phases of wound healing. The inflammatory phase is marked by platelet accumulation, coagulation, and leukocyte migration. The proliferative phase is characterized by re-epithelialization, angiogenesis, fibroplasia, and wound contraction. Finally, the remodeling phase takes place over a period of months, during which the dermis responds to injury with the production of collagen and matrix proteins and then returns to its preinjury phenotype. The second part of this review outlines selected practical clinical aspects of wound repair. That section is subdivided into acute and chronic wounds. We describe the difference between primary and secondary intention healing and discuss factors that affect healing in both. We also describe our systemic approach to dealing with patients with chronic wounds and present our problem-oriented treatment program based on the cause of the chronic wound.

Original languageEnglish
Pages (from-to)629-640
Number of pages12
JournalDermatologic Clinics
Volume11
Issue number4
StatePublished - Jan 1 1993

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Wound Healing
Wounds and Injuries
Re-Epithelialization
Dermis
Leukocytes
Collagen
Blood Platelets
Phenotype
Proteins

ASJC Scopus subject areas

  • Dermatology

Cite this

Kirsner, R., & Eaglstein, W. H. (1993). The wound healing process. Dermatologic Clinics, 11(4), 629-640.

The wound healing process. / Kirsner, Robert; Eaglstein, W. H.

In: Dermatologic Clinics, Vol. 11, No. 4, 01.01.1993, p. 629-640.

Research output: Contribution to journalArticle

Kirsner, R & Eaglstein, WH 1993, 'The wound healing process', Dermatologic Clinics, vol. 11, no. 4, pp. 629-640.
Kirsner R, Eaglstein WH. The wound healing process. Dermatologic Clinics. 1993 Jan 1;11(4):629-640.
Kirsner, Robert ; Eaglstein, W. H. / The wound healing process. In: Dermatologic Clinics. 1993 ; Vol. 11, No. 4. pp. 629-640.
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