Abstract
Topical antimicrobials are widely used to control wound bioburden and facilitate wound healing; however, the fine balance between antimicrobial efficacy and non-toxicity must be achieved. This study evaluated whether an anti-biofilm silver-containing wound dressing interfered with the normal healing process in non-contaminated deep partial thickness wounds. In an in-vivo porcine wound model using 2 pigs, 96 wounds were randomly assigned to 1 of 3 dressing groups: anti-biofilm silver Hydrofiber dressing (test), silver Hydrofiber dressing (control), or polyurethane film dressing (control). Wounds were investigated for 8 days, and wound biopsies (n = 4) were taken from each dressing group, per animal, on days 2, 4, 6, and 8 after wounding and evaluated using light microscopy. No statistically significant differences were observed in the rate of reepithelialisation, white blood cell infiltration, angiogenesis, or granulation tissue formation following application of the anti-biofilm silver Hydrofiber dressing versus the 2 control dressings. Overall, epithelial thickness was similar between groups. Some differences in infiltration of specific cell types were observed between groups. There were no signs of tissue necrosis, fibrosis, or fatty infiltration in any group. An anti-biofilm silver Hydrofiber wound dressing did not cause any notable interference with normal healing processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 834-839 |
| Number of pages | 6 |
| Journal | International Wound Journal |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2018 |
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Keywords
- anti-biofilm dressings
- healing
- partial thickness wounds
- porcine model
- silver
ASJC Scopus subject areas
- Surgery
- Dermatology
Cite this
The wound-healing effects of a next-generation anti-biofilm silver Hydrofiber wound dressing on deep partial-thickness wounds using a porcine model. / Davis, Stephen C; Li, Jie; Gil Rodriguez, Joel; Valdes, Jose; Solis, Michael; Higa, Alex; Bowler, Philip.
In: International Wound Journal, Vol. 15, No. 5, 01.10.2018, p. 834-839.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The wound-healing effects of a next-generation anti-biofilm silver Hydrofiber wound dressing on deep partial-thickness wounds using a porcine model
AU - Davis, Stephen C
AU - Li, Jie
AU - Gil Rodriguez, Joel
AU - Valdes, Jose
AU - Solis, Michael
AU - Higa, Alex
AU - Bowler, Philip
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Topical antimicrobials are widely used to control wound bioburden and facilitate wound healing; however, the fine balance between antimicrobial efficacy and non-toxicity must be achieved. This study evaluated whether an anti-biofilm silver-containing wound dressing interfered with the normal healing process in non-contaminated deep partial thickness wounds. In an in-vivo porcine wound model using 2 pigs, 96 wounds were randomly assigned to 1 of 3 dressing groups: anti-biofilm silver Hydrofiber dressing (test), silver Hydrofiber dressing (control), or polyurethane film dressing (control). Wounds were investigated for 8 days, and wound biopsies (n = 4) were taken from each dressing group, per animal, on days 2, 4, 6, and 8 after wounding and evaluated using light microscopy. No statistically significant differences were observed in the rate of reepithelialisation, white blood cell infiltration, angiogenesis, or granulation tissue formation following application of the anti-biofilm silver Hydrofiber dressing versus the 2 control dressings. Overall, epithelial thickness was similar between groups. Some differences in infiltration of specific cell types were observed between groups. There were no signs of tissue necrosis, fibrosis, or fatty infiltration in any group. An anti-biofilm silver Hydrofiber wound dressing did not cause any notable interference with normal healing processes.
AB - Topical antimicrobials are widely used to control wound bioburden and facilitate wound healing; however, the fine balance between antimicrobial efficacy and non-toxicity must be achieved. This study evaluated whether an anti-biofilm silver-containing wound dressing interfered with the normal healing process in non-contaminated deep partial thickness wounds. In an in-vivo porcine wound model using 2 pigs, 96 wounds were randomly assigned to 1 of 3 dressing groups: anti-biofilm silver Hydrofiber dressing (test), silver Hydrofiber dressing (control), or polyurethane film dressing (control). Wounds were investigated for 8 days, and wound biopsies (n = 4) were taken from each dressing group, per animal, on days 2, 4, 6, and 8 after wounding and evaluated using light microscopy. No statistically significant differences were observed in the rate of reepithelialisation, white blood cell infiltration, angiogenesis, or granulation tissue formation following application of the anti-biofilm silver Hydrofiber dressing versus the 2 control dressings. Overall, epithelial thickness was similar between groups. Some differences in infiltration of specific cell types were observed between groups. There were no signs of tissue necrosis, fibrosis, or fatty infiltration in any group. An anti-biofilm silver Hydrofiber wound dressing did not cause any notable interference with normal healing processes.
KW - anti-biofilm dressings
KW - healing
KW - partial thickness wounds
KW - porcine model
KW - silver
UR - http://www.scopus.com/inward/record.url?scp=85053437070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053437070&partnerID=8YFLogxK
U2 - 10.1111/iwj.12935
DO - 10.1111/iwj.12935
M3 - Article
C2 - 29893025
AN - SCOPUS:85053437070
VL - 15
SP - 834
EP - 839
JO - International Wound Journal
JF - International Wound Journal
SN - 1742-4801
IS - 5
ER -