The wonders of 2-deoxy-d-glucose

Haibin Xi, Metin Kurtoglu, Theodore Lampidis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.

Original languageEnglish
Pages (from-to)110-121
Number of pages12
JournalIUBMB Life
Volume66
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Glucose
Virus Diseases
Epilepsy
Neoplasms
Aging of materials
Morbidity
Molecules

Keywords

  • 2-deoxy- d -glucose
  • apoptosis
  • autophagy
  • endoplasmic reticulum stress
  • glycosylation
  • hypoxia
  • viral replication

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

The wonders of 2-deoxy-d-glucose. / Xi, Haibin; Kurtoglu, Metin; Lampidis, Theodore.

In: IUBMB Life, Vol. 66, No. 2, 01.01.2014, p. 110-121.

Research output: Contribution to journalArticle

Xi, H, Kurtoglu, M & Lampidis, T 2014, 'The wonders of 2-deoxy-d-glucose', IUBMB Life, vol. 66, no. 2, pp. 110-121. https://doi.org/10.1002/iub.1251
Xi, Haibin ; Kurtoglu, Metin ; Lampidis, Theodore. / The wonders of 2-deoxy-d-glucose. In: IUBMB Life. 2014 ; Vol. 66, No. 2. pp. 110-121.
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