The wonders of 2-deoxy-d-glucose

Haibin Xi, Metin Kurtoglu, Theodore J. Lampidis

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.

Original languageEnglish (US)
Pages (from-to)110-121
Number of pages12
JournalIUBMB life
Volume66
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • 2-deoxy- d -glucose
  • apoptosis
  • autophagy
  • endoplasmic reticulum stress
  • glycosylation
  • hypoxia
  • viral replication

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'The wonders of 2-deoxy-d-glucose'. Together they form a unique fingerprint.

Cite this