The wonders of 2-deoxy-d-glucose

Haibin Xi, Metin Kurtoglu, Theodore J. Lampidis

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.

Original languageEnglish (US)
Pages (from-to)110-121
Number of pages12
JournalIUBMB life
Issue number2
StatePublished - Feb 2014


  • 2-deoxy- d -glucose
  • apoptosis
  • autophagy
  • endoplasmic reticulum stress
  • glycosylation
  • hypoxia
  • viral replication

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics


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