The virtue of just enough stress: a molecular model.

Nanette H. Bishopric

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Molecular biology emphasizes the study of all-or-nothing phenomena and molecular events with a large dynamic range. However, many important physiologic parameters in the clinical setting are tightly constrained (e.g., serum sodium concentration, body mass, venous oxygen saturation, sleep duration). Stress responses exhibit both a wide dynamic range and a potential for important effects at a "just-enough" threshold activation level. Stress responses occur in a number of body systems (e.g., neuropsychiatric, immune, cardiovascular) and are essential for short-term damage control, but also must be tightly constrained in range and duration to permit the organism to walk the narrow homeostatic path to long-term survival. Using an example of a newly appreciated stress-responsive molecule in the heart, acetyltransferase p300, as well as examples from the literature, this article discusses the advantages of self-limited stress, the adverse effects of sustained stress, and the built-in mechanisms that feed back on and terminate stress signals, and advances a hypothesis regarding stress as a pharmacological target in the heart.

Original languageEnglish (US)
Pages (from-to)175-191; discussion 191-192
JournalUnknown Journal
Volume123
StatePublished - 2012

ASJC Scopus subject areas

  • Medicine(all)

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