The virtual international stroke trials archive

Myzoon Ali, Philip M W Bath, John Curram, Stephen M. Davis, Hans Christoph Diener, Geoffrey A. Donnan, Marc Fisher, Barbara A. Gregson, James Grotta, Werner Hacke, Michael G. Hennerici, Marc Hommel, Markku Kaste, John R. Marler, Ralph L Sacco, Philip Teal, Nils Gunnar Wahlgren, Steven Warach, Christopher J. Weir, Kennedy R. Lees

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69±12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.

Original languageEnglish
Pages (from-to)1905-1910
Number of pages6
JournalStroke
Volume38
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

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Keywords

  • Clinical trials
  • Database
  • Modified Rankin Scale
  • National Institutes of Health Stroke Scale
  • Natural history
  • Trial design

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Ali, M., Bath, P. M. W., Curram, J., Davis, S. M., Diener, H. C., Donnan, G. A., Fisher, M., Gregson, B. A., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M., Kaste, M., Marler, J. R., Sacco, R. L., Teal, P., Wahlgren, N. G., Warach, S., Weir, C. J., & Lees, K. R. (2007). The virtual international stroke trials archive. Stroke, 38(6), 1905-1910. https://doi.org/10.1161/STROKEAHA.106.473579