The value of radionuclide scanning in early diagnosis of intestinal infarction

Victor N. Ortiz, George Sfakianakis, Gerald M. Haase, E. Thomas Boles

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Small focal areas of intestinal infarction were produced experimentally in mice by two techniques: (1) intussusception and (2) suture strangulation of a loop of jejunum. The radionuclide technetium 99m diphosphonate (99mTc-diphosphonate) was subsequently administered intravenously, and abdominal scans were obtained. The scans demonstrated focal infarcted lesions accurately, and every positive scan was associated with an area of infarction, as demonstrated by pathologic examination. However, negative scans did not definitely exclude an area of infarction: in the intussuception study there were five false negative scans in 25 animals, and in the loop ligation study there were two false negative scans in 28 animals. The technique may have clinical application in such intestinal diseases as necrotizing enterocolitis in infancy in which early diagnosis of small areas of necrosis is currently difficult by clinical and radiologic methods.

Original languageEnglish (US)
Pages (from-to)616-621
Number of pages6
JournalJournal of Pediatric Surgery
Issue number6 SUPPL.
StatePublished - Dec 1978


  • intestinal infarction (necrosis)
  • Radionuclide abdominal scanning

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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