Abstract
Small focal areas of intestinal infarction were produced experimentally in mice by two techniques: (1) intussusception and (2) suture strangulation of a loop of jejunum. The radionuclide technetium 99m diphosphonate (99mTc-diphosphonate) was subsequently administered intravenously, and abdominal scans were obtained. The scans demonstrated focal infarcted lesions accurately, and every positive scan was associated with an area of infarction, as demonstrated by pathologic examination. However, negative scans did not definitely exclude an area of infarction: in the intussuception study there were five false negative scans in 25 animals, and in the loop ligation study there were two false negative scans in 28 animals. The technique may have clinical application in such intestinal diseases as necrotizing enterocolitis in infancy in which early diagnosis of small areas of necrosis is currently difficult by clinical and radiologic methods.
| Original language | English |
|---|---|
| Pages (from-to) | 616-621 |
| Number of pages | 6 |
| Journal | Journal of Pediatric Surgery |
| Volume | 13 |
| Issue number | 6 SUPPL. |
| DOIs | |
| State | Published - Jan 1 1978 |
| Externally published | Yes |
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Keywords
- intestinal infarction (necrosis)
- Radionuclide abdominal scanning
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery
Cite this
The value of radionuclide scanning in early diagnosis of intestinal infarction. / Ortiz, Victor N.; Sfakianakis, George N; Haase, Gerald M.; Boles, E. Thomas.
In: Journal of Pediatric Surgery, Vol. 13, No. 6 SUPPL., 01.01.1978, p. 616-621.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The value of radionuclide scanning in early diagnosis of intestinal infarction
AU - Ortiz, Victor N.
AU - Sfakianakis, George N
AU - Haase, Gerald M.
AU - Boles, E. Thomas
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Small focal areas of intestinal infarction were produced experimentally in mice by two techniques: (1) intussusception and (2) suture strangulation of a loop of jejunum. The radionuclide technetium 99m diphosphonate (99mTc-diphosphonate) was subsequently administered intravenously, and abdominal scans were obtained. The scans demonstrated focal infarcted lesions accurately, and every positive scan was associated with an area of infarction, as demonstrated by pathologic examination. However, negative scans did not definitely exclude an area of infarction: in the intussuception study there were five false negative scans in 25 animals, and in the loop ligation study there were two false negative scans in 28 animals. The technique may have clinical application in such intestinal diseases as necrotizing enterocolitis in infancy in which early diagnosis of small areas of necrosis is currently difficult by clinical and radiologic methods.
AB - Small focal areas of intestinal infarction were produced experimentally in mice by two techniques: (1) intussusception and (2) suture strangulation of a loop of jejunum. The radionuclide technetium 99m diphosphonate (99mTc-diphosphonate) was subsequently administered intravenously, and abdominal scans were obtained. The scans demonstrated focal infarcted lesions accurately, and every positive scan was associated with an area of infarction, as demonstrated by pathologic examination. However, negative scans did not definitely exclude an area of infarction: in the intussuception study there were five false negative scans in 25 animals, and in the loop ligation study there were two false negative scans in 28 animals. The technique may have clinical application in such intestinal diseases as necrotizing enterocolitis in infancy in which early diagnosis of small areas of necrosis is currently difficult by clinical and radiologic methods.
KW - intestinal infarction (necrosis)
KW - Radionuclide abdominal scanning
UR - http://www.scopus.com/inward/record.url?scp=0018114844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018114844&partnerID=8YFLogxK
U2 - 10.1016/S0022-3468(78)80103-1
DO - 10.1016/S0022-3468(78)80103-1
M3 - Article
C2 - 731361
AN - SCOPUS:0018114844
VL - 13
SP - 616
EP - 621
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 6 SUPPL.
ER -