The use of thermal treatments to enhance the mechanical properties of electrospun poly(ε-caprolactone) scaffolds

Sang Jin Lee, Se Heang Oh, Jie Liu, Shay Soker, Anthony Atala, James J. Yoo

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Nonwoven nanofiber scaffolds fabricated by electrospinning technology have been widely used for tissue engineering applications. Although electrospun nanofiber scaffolds fulfill many requirements for tissue engineering applications, they sometimes lack the necessary biomechanical properties. To attempt to improve the biomechanical properties of electrospun poly(ε-caprolactone) (PCL) scaffolds, fibers were bonded by thermal treatment. The thermal fiber bonding was performed in Pluronic F127 solution at a range of temperatures from 54 °C to 60 °C. Thermally bonded electrospun PCL scaffolds were characterized by analyzing the changes in morphology, fiber diameter, pore area, tensile properties, suture retention strength, burst pressure strength, and compliance. The biomechanical properties of the thermally bonded electrospun PCL scaffolds were significantly increased without any gross observable and ultrastructural changes when compared to untreated PCL scaffolds. This study suggests that the introduction of thermal fiber bonding to electrospun PCL scaffolds improved the biomechanical properties of these scaffolds, making them more suitable for tissue engineering applications.

Original languageEnglish
Pages (from-to)1422-1430
Number of pages9
JournalBiomaterials
Volume29
Issue number10
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Tissue Engineering
Scaffolds
Nanofibers
UCON 50-HB-5100
Hot Temperature
Heat treatment
Scaffolds (biology)
Mechanical properties
Tissue engineering
Fiber bonding
Poloxamer
Sutures
Compliance
Fibers
Technology
Electrospinning
Pressure
Temperature
Tensile properties
polycaprolactone

Keywords

  • Electrospinning
  • Mechanical properties
  • Polycaprolactone
  • Scaffold
  • Thermal fiber bonding
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

The use of thermal treatments to enhance the mechanical properties of electrospun poly(ε-caprolactone) scaffolds. / Lee, Sang Jin; Oh, Se Heang; Liu, Jie; Soker, Shay; Atala, Anthony; Yoo, James J.

In: Biomaterials, Vol. 29, No. 10, 01.04.2008, p. 1422-1430.

Research output: Contribution to journalArticle

Lee, Sang Jin ; Oh, Se Heang ; Liu, Jie ; Soker, Shay ; Atala, Anthony ; Yoo, James J. / The use of thermal treatments to enhance the mechanical properties of electrospun poly(ε-caprolactone) scaffolds. In: Biomaterials. 2008 ; Vol. 29, No. 10. pp. 1422-1430.
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