Abstract
Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.
| Original language | English |
|---|---|
| Pages (from-to) | 401-411 |
| Number of pages | 11 |
| Journal | Seminars in Neuroscience |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1993 |
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Keywords
- axonal central nervous system regeneration
- mammalian spinal cord
- polymeric channels
- Schwann cell transplantation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The use of schwann cell transplantation to foster central nervous system repair. / Guénard, Véronique; Xu, Xiao Ming; Bunge, Mary B.
In: Seminars in Neuroscience, Vol. 5, No. 6, 01.01.1993, p. 401-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of schwann cell transplantation to foster central nervous system repair
AU - Guénard, Véronique
AU - Xu, Xiao Ming
AU - Bunge, Mary B
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.
AB - Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.
KW - axonal central nervous system regeneration
KW - mammalian spinal cord
KW - polymeric channels
KW - Schwann cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=0027749098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027749098&partnerID=8YFLogxK
U2 - 10.1016/S1044-5765(05)80012-0
DO - 10.1016/S1044-5765(05)80012-0
M3 - Article
VL - 5
SP - 401
EP - 411
JO - Seminars in the Neurosciences
JF - Seminars in the Neurosciences
SN - 1044-5765
IS - 6
ER -