The use of schwann cell transplantation to foster central nervous system repair

Véronique Guénard, Xiao Ming Xu, Mary B Bunge

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.

Original languageEnglish
Pages (from-to)401-411
Number of pages11
JournalSeminars in Neuroscience
Volume5
Issue number6
DOIs
StatePublished - Jan 1 1993

Fingerprint

Schwann Cells
Cell Transplantation
Central Nervous System
Nervous System Trauma
Diencephalon
Axons
Regeneration
Spinal Cord
Suspensions
Transplantation
Transplants
Neurons
Injections
Population

Keywords

  • axonal central nervous system regeneration
  • mammalian spinal cord
  • polymeric channels
  • Schwann cell transplantation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The use of schwann cell transplantation to foster central nervous system repair. / Guénard, Véronique; Xu, Xiao Ming; Bunge, Mary B.

In: Seminars in Neuroscience, Vol. 5, No. 6, 01.01.1993, p. 401-411.

Research output: Contribution to journalArticle

Guénard, Véronique ; Xu, Xiao Ming ; Bunge, Mary B. / The use of schwann cell transplantation to foster central nervous system repair. In: Seminars in Neuroscience. 1993 ; Vol. 5, No. 6. pp. 401-411.
@article{5326d28a887f46c6b5f840a593137b6d,
title = "The use of schwann cell transplantation to foster central nervous system repair",
abstract = "Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.",
keywords = "axonal central nervous system regeneration, mammalian spinal cord, polymeric channels, Schwann cell transplantation",
author = "V{\'e}ronique Gu{\'e}nard and Xu, {Xiao Ming} and Bunge, {Mary B}",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/S1044-5765(05)80012-0",
language = "English",
volume = "5",
pages = "401--411",
journal = "Seminars in the Neurosciences",
issn = "1044-5765",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - The use of schwann cell transplantation to foster central nervous system repair

AU - Guénard, Véronique

AU - Xu, Xiao Ming

AU - Bunge, Mary B

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.

AB - Schwann cells (SCs) have been a key element in the demonstration of the ability of central nervous system (CNS) neurons to regenerate when provided with an appropriate environment. SCs transplanted into injured adult mammalian CNS (including the optic and septo-hippocampal systems, spinal cord and diencephalon) survive, promote axonal regeneration, and ensheathe or myelinate the regenerated axons. Methods to graft SCs into the lesioned CNS range from injection of a SC suspension to transplantation of more elaborate SC constructs using polymeric bridges. We discuss in detail the use of semipermeable guidance channels seeded with purified populations of SCs. These studies suggest that the ability of SCs to function in various injured CNS regions might lead to new avenues for the treatment of CNS injuries and demyelinating conditions in the human.

KW - axonal central nervous system regeneration

KW - mammalian spinal cord

KW - polymeric channels

KW - Schwann cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=0027749098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027749098&partnerID=8YFLogxK

U2 - 10.1016/S1044-5765(05)80012-0

DO - 10.1016/S1044-5765(05)80012-0

M3 - Article

VL - 5

SP - 401

EP - 411

JO - Seminars in the Neurosciences

JF - Seminars in the Neurosciences

SN - 1044-5765

IS - 6

ER -