The use of poly(styrene-block-isobutyleneblock- styrene) as a microshunt to treat glaucoma

Leonard Pinchuk, Isabelle Riss, Juan F. Batlle, Yasushi P. Kato, John B. Martin, Esdras Arrieta, Paul Palmberg, Richard K. Parrish, Bruce A.Weber, Yongmoon Kwon, Jean Marie Parel

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The InnFocus MicroShuntVR is a minimally invasive glaucoma drainage microtube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon's capsule. The safety and clinical performance of this device approaches that of trabeculectomy with mitomycin C, the current 'gold standard' treatment for advanced glaucoma. The invention of a new biomaterial called poly(styrene-block-isobutylene-block-styrene) or 'SIBS' is the enabling factor which led to the success of this product. SIBS is ultrastable with virtually no foreign body reaction in the body, which manifests as clinically insignificant inflammation and capsule formation in the eye. The lack of capsule formation enables unobstructed flow through the 70 μm lumen tube and the achievement of controlled low intraocular pressure, which is important for the management of glaucoma. This article summarizes the integration of SIBS into a glaucoma drainage device and confirms its functionality with clinical success over a 2-year period.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalRegenerative Biomaterials
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2016

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Keywords

  • Biocompatibility
  • Medical device
  • Soft tissue
  • Stent

ASJC Scopus subject areas

  • Biomaterials

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