The use of keratin-based wound products on refractory wounds

Annette T. Batzer, Clive Marsh, Robert Kirsner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non-healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non-healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin-based novel topical wound healing products. Thirty-seven wounds or 82% of wounds were either healed or reduced in size of >50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalInternational Wound Journal
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Keratins
Wounds and Injuries
Wound Healing
Varicose Ulcer
Wound Infection
Therapeutics
Bandages
Cell Movement
Cell Differentiation
Proteins
Down-Regulation
Phenotype
Gene Expression
Growth

Keywords

  • Chronic wounds
  • Keratin
  • Leg ulcers

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

The use of keratin-based wound products on refractory wounds. / Batzer, Annette T.; Marsh, Clive; Kirsner, Robert.

In: International Wound Journal, Vol. 13, No. 1, 01.02.2016, p. 110-115.

Research output: Contribution to journalArticle

Batzer, Annette T. ; Marsh, Clive ; Kirsner, Robert. / The use of keratin-based wound products on refractory wounds. In: International Wound Journal. 2016 ; Vol. 13, No. 1. pp. 110-115.
@article{b68d01917013486ca740eca87261dc28,
title = "The use of keratin-based wound products on refractory wounds",
abstract = "Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non-healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non-healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin-based novel topical wound healing products. Thirty-seven wounds or 82{\%} of wounds were either healed or reduced in size of >50{\%} during treatment, with 29 (64{\%}) healing completely and an additional 8 wounds experiencing 50{\%} wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.",
keywords = "Chronic wounds, Keratin, Leg ulcers",
author = "Batzer, {Annette T.} and Clive Marsh and Robert Kirsner",
year = "2016",
month = "2",
day = "1",
doi = "10.1111/iwj.12245",
language = "English (US)",
volume = "13",
pages = "110--115",
journal = "International Wound Journal",
issn = "1742-4801",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The use of keratin-based wound products on refractory wounds

AU - Batzer, Annette T.

AU - Marsh, Clive

AU - Kirsner, Robert

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non-healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non-healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin-based novel topical wound healing products. Thirty-seven wounds or 82% of wounds were either healed or reduced in size of >50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.

AB - Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non-healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non-healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin-based novel topical wound healing products. Thirty-seven wounds or 82% of wounds were either healed or reduced in size of >50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.

KW - Chronic wounds

KW - Keratin

KW - Leg ulcers

UR - http://www.scopus.com/inward/record.url?scp=84955678358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955678358&partnerID=8YFLogxK

U2 - 10.1111/iwj.12245

DO - 10.1111/iwj.12245

M3 - Article

C2 - 24580740

AN - SCOPUS:84955678358

VL - 13

SP - 110

EP - 115

JO - International Wound Journal

JF - International Wound Journal

SN - 1742-4801

IS - 1

ER -