The use of keratin-based wound products on refractory wounds

Annette T. Batzer, Clive Marsh, Robert Kirsner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non-healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non-healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin-based novel topical wound healing products. Thirty-seven wounds or 82% of wounds were either healed or reduced in size of >50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalInternational Wound Journal
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2016

Keywords

  • Chronic wounds
  • Keratin
  • Leg ulcers

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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