The use of chlorambucil with prednisone in the treatment of pemphigus

Neha Shah, Andy R. Green, George Elgart, Francisco Kerdel

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Chlorambucil is an alkylating agent that preferentially affects B cells over T cells and has been shown to be effective in the treatment of bullous pemphigoid. Objective: Our purpose was to determine whether chlorambucil is effective in the treatment of pemphigus. Methods: We retrospectively reviewed the medical records of 9 patients with pemphigus (7 with pemphigus vulgaris and 2 with pemphigus foliaceus) in whom therapy with other immunosuppressive regimens failed and who were subsequently treated with chlorambucil and prednisone. Results: There was clinical improvement in 6 of 9 patients and a decrease in indirect immunofluoresent antibody titers in 3 of the 5 patients who had titers drawn before and after treatment with chlorambucil. Three of the 9 patients failed treatment with chlorambucil, as evidenced by lack of improvement of lesions. Conclusion: Chlorambucil may be a potential adjuvant therapeutic approach with steroid-sparing effects in patients with pemphigus who have failed treatment with other immunosuppressive regimens.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume42
Issue number1 I
StatePublished - Jan 1 2000

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Chlorambucil
Pemphigus
Prednisone
Immunosuppressive Agents
Therapeutics
Bullous Pemphigoid
Alkylating Agents
Medical Records
B-Lymphocytes
Steroids
T-Lymphocytes
Antibodies

ASJC Scopus subject areas

  • Dermatology

Cite this

The use of chlorambucil with prednisone in the treatment of pemphigus. / Shah, Neha; Green, Andy R.; Elgart, George; Kerdel, Francisco.

In: Journal of the American Academy of Dermatology, Vol. 42, No. 1 I, 01.01.2000, p. 85-88.

Research output: Contribution to journalArticle

Shah, Neha ; Green, Andy R. ; Elgart, George ; Kerdel, Francisco. / The use of chlorambucil with prednisone in the treatment of pemphigus. In: Journal of the American Academy of Dermatology. 2000 ; Vol. 42, No. 1 I. pp. 85-88.
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