The use of chlorambucil with prednisone in the treatment of pemphigus

Neha Shah, Andy R. Green, George W. Elgart, Francisco Kerdel

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Chlorambucil is an alkylating agent that preferentially affects B cells over T cells and has been shown to be effective in the treatment of bullous pemphigoid. Objective: Our purpose was to determine whether chlorambucil is effective in the treatment of pemphigus. Methods: We retrospectively reviewed the medical records of 9 patients with pemphigus (7 with pemphigus vulgaris and 2 with pemphigus foliaceus) in whom therapy with other immunosuppressive regimens failed and who were subsequently treated with chlorambucil and prednisone. Results: There was clinical improvement in 6 of 9 patients and a decrease in indirect immunofluoresent antibody titers in 3 of the 5 patients who had titers drawn before and after treatment with chlorambucil. Three of the 9 patients failed treatment with chlorambucil, as evidenced by lack of improvement of lesions. Conclusion: Chlorambucil may be a potential adjuvant therapeutic approach with steroid-sparing effects in patients with pemphigus who have failed treatment with other immunosuppressive regimens.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalJournal of the American Academy of Dermatology
Issue number1 I
StatePublished - Jan 2000

ASJC Scopus subject areas

  • Dermatology


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