The use of brincidofovir for the treatment of mixed dsDNA viral infection

Jose Camargo Galvis; Michele I Morris; Lilian Abbo; Jacques Simkins-Cohen; Seyyedeh Saneeymehri; Maritza C. Alencar; Lazaros Lekakis; Krishna V Komanduri

doi:10.1016/j.jcv.2016.07.021

The use of brincidofovir for the treatment of mixed dsDNA viral infection

Jose Camargo Galvis, Michele I Morris, Lilian Abbo, Jacques Simkins-Cohen, Seyyedeh Saneeymehri, Maritza C. Alencar, Lazaros Lekakis, Krishna V Komanduri

Medicine

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Journal of Clinical Virology
Volume	83
DOIs	https://doi.org/10.1016/j.jcv.2016.07.021
State	Published - Oct 1 2016

Keywords

Adenovirus
BK virus
Brincidofovir
CMX001
Cytomegalovirus
Epstein–Barr virus

ASJC Scopus subject areas

Medicine(all)
Virology
Infectious Diseases

Access to Document

10.1016/j.jcv.2016.07.021

Fingerprint Dive into the research topics of 'The use of brincidofovir for the treatment of mixed dsDNA viral infection'. Together they form a unique fingerprint.

Cite this

Camargo Galvis, J., Morris, M. I., Abbo, L., Simkins-Cohen, J., Saneeymehri, S., Alencar, M. C., Lekakis, L., & Komanduri, K. V. (2016). The use of brincidofovir for the treatment of mixed dsDNA viral infection. Journal of Clinical Virology, 83, 1-4. https://doi.org/10.1016/j.jcv.2016.07.021

@article{69941d17f44440a3bdd428eef24c7dd5,

title = "The use of brincidofovir for the treatment of mixed dsDNA viral infection",

abstract = "Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.",

keywords = "Adenovirus, BK virus, Brincidofovir, CMX001, Cytomegalovirus, Epstein–Barr virus",

author = "{Camargo Galvis}, Jose and Morris, {Michele I} and Lilian Abbo and Jacques Simkins-Cohen and Seyyedeh Saneeymehri and Alencar, {Maritza C.} and Lazaros Lekakis and Komanduri, {Krishna V}",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.jcv.2016.07.021",

language = "English (US)",

volume = "83",

pages = "1--4",

journal = "Journal of Clinical Virology",

issn = "1386-6532",

publisher = "Elsevier",

}

TY - JOUR

T1 - The use of brincidofovir for the treatment of mixed dsDNA viral infection

AU - Camargo Galvis, Jose

AU - Morris, Michele I

AU - Abbo, Lilian

AU - Simkins-Cohen, Jacques

AU - Saneeymehri, Seyyedeh

AU - Alencar, Maritza C.

AU - Lekakis, Lazaros

AU - Komanduri, Krishna V

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.

AB - Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.

KW - Adenovirus

KW - BK virus

KW - Brincidofovir

KW - CMX001

KW - Cytomegalovirus

KW - Epstein–Barr virus

UR - http://www.scopus.com/inward/record.url?scp=84982803413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982803413&partnerID=8YFLogxK

U2 - 10.1016/j.jcv.2016.07.021

DO - 10.1016/j.jcv.2016.07.021

M3 - Article

C2 - 27513204

AN - SCOPUS:84982803413

VL - 83

SP - 1

EP - 4

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

SN - 1386-6532

ER -