TY - JOUR
T1 - The use of brincidofovir for the treatment of mixed dsDNA viral infection
AU - Camargo Galvis, Jose
AU - Morris, Michele I
AU - Abbo, Lilian
AU - Simkins-Cohen, Jacques
AU - Saneeymehri, Seyyedeh
AU - Alencar, Maritza C.
AU - Lekakis, Lazaros
AU - Komanduri, Krishna V
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.
AB - Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.
KW - Adenovirus
KW - BK virus
KW - Brincidofovir
KW - CMX001
KW - Cytomegalovirus
KW - Epstein–Barr virus
UR - http://www.scopus.com/inward/record.url?scp=84982803413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982803413&partnerID=8YFLogxK
U2 - 10.1016/j.jcv.2016.07.021
DO - 10.1016/j.jcv.2016.07.021
M3 - Article
C2 - 27513204
AN - SCOPUS:84982803413
VL - 83
SP - 1
EP - 4
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
ER -