The use of brincidofovir for the treatment of mixed dsDNA viral infection

Jose Camargo Galvis; Michele I Morris; Lilian Abbo; Jacques Simkins-Cohen; Seyyedeh Saneeymehri; Maritza C. Alencar; Lazaros Lekakis; Krishna V Komanduri

doi:10.1016/j.jcv.2016.07.021

The use of brincidofovir for the treatment of mixed dsDNA viral infection

Jose Camargo Galvis, Michele I Morris, Lilian Abbo, Jacques Simkins-Cohen, Seyyedeh Saneeymehri, Maritza C. Alencar, Lazaros Lekakis, Krishna V Komanduri

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Journal of Clinical Virology
Volume	83
DOIs	https://doi.org/10.1016/j.jcv.2016.07.021
State	Published - Oct 1 2016

Keywords

Adenovirus
BK virus
Brincidofovir
CMX001
Cytomegalovirus
Epstein–Barr virus

ASJC Scopus subject areas

Medicine(all)
Virology
Infectious Diseases

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The use of brincidofovir for the treatment of mixed dsDNA viral infection. / Camargo Galvis, Jose ; Morris, Michele I ; Abbo, Lilian ; Simkins-Cohen, Jacques; Saneeymehri, Seyyedeh; Alencar, Maritza C.; Lekakis, Lazaros ; Komanduri, Krishna V.

In: Journal of Clinical Virology, Vol. 83, 01.10.2016, p. 1-4.

Research output: Contribution to journal › Article › peer-review

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abstract = "Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein–Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.",

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