The use of antioxidants in radiotherapy-induced skin toxicity

Kyle T. Amber, Michael I. Shiman, Evangelos V. Badiavas

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalIntegrative Cancer Therapies
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • antioxidants
  • flavone
  • oncology
  • polyphenol
  • radiation therapy
  • radiodermatitis
  • radiotherapy
  • skin fibrosis

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Oncology

Fingerprint Dive into the research topics of 'The use of antioxidants in radiotherapy-induced skin toxicity'. Together they form a unique fingerprint.

  • Cite this