The use of amantadine HCL in clinical practice: A study of old and new indications

Carlos Singer, Spiridon Papapetropoulos, Gadith Uzcategui, Lydia Vela

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Since the discovery of the anti-dyskinetic properties of amantadine, there has been a renewed interest in its use. To evaluate its efficacy and tolerability, we performed a retrospective study of consecutive patients with Parkinson's disease (PD) who had received amantadine either as mono- or combination therapy for a 3-year period. We identified 41 patients. Nineteen (46%) experienced amantadine-related side effects. Eleven (27%) discontinued treatment before 1 year. Although dyskinesias improved (to some extent) in all patients after amantadine treatment, only 73.3% experienced improvement of motor symptoms. In conclusion, amantadine was effective in the treatment PD for at least 1 year in 40% of our patients.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalJournal of Applied Research
Issue number3
StatePublished - Nov 21 2006


  • Amantadine
  • Clinical practice
  • Dyskinesias
  • Side-effects

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology


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