The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer

H. B. Niell, M. S. Soloway, C. A. Wood, L. W. McCallum, K. Webster

Research output: Contribution to journalArticle

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Abstract

A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum criteria for drug response, the TCA accurately predicted drug responses in the murine model 65% of the time with a true-positive predictive rate of 54% and a true-negative predictive rate of 70%. Drug testing tumor cells immediately on removal from the mouse resulted in a true-positive predictive rate of 77% and a true-negative predictive rate of 100%. The authors conclude that the TCA can predict response to chemotherapy in the MBT model and may be useful in screening investigation compounds for the subsequent evaluation in this murine bladder tumor model.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalCancer
Volume52
Issue number4
StatePublished - Sep 23 1983

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Urinary Bladder Neoplasms
Pharmaceutical Preparations
Neoplasms
FANFT
Tumor Cell Line
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Niell, H. B., Soloway, M. S., Wood, C. A., McCallum, L. W., & Webster, K. (1983). The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer. Cancer, 52(4), 619-625.

The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer. / Niell, H. B.; Soloway, M. S.; Wood, C. A.; McCallum, L. W.; Webster, K.

In: Cancer, Vol. 52, No. 4, 23.09.1983, p. 619-625.

Research output: Contribution to journalArticle

Niell, HB, Soloway, MS, Wood, CA, McCallum, LW & Webster, K 1983, 'The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer', Cancer, vol. 52, no. 4, pp. 619-625.
Niell HB, Soloway MS, Wood CA, McCallum LW, Webster K. The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer. Cancer. 1983 Sep 23;52(4):619-625.
Niell, H. B. ; Soloway, M. S. ; Wood, C. A. ; McCallum, L. W. ; Webster, K. / The use of a tumor colony assay in predicting chemotherapeutic drug response in murine bladder cancer. In: Cancer. 1983 ; Vol. 52, No. 4. pp. 619-625.
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abstract = "A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum criteria for drug response, the TCA accurately predicted drug responses in the murine model 65{\%} of the time with a true-positive predictive rate of 54{\%} and a true-negative predictive rate of 70{\%}. Drug testing tumor cells immediately on removal from the mouse resulted in a true-positive predictive rate of 77{\%} and a true-negative predictive rate of 100{\%}. The authors conclude that the TCA can predict response to chemotherapy in the MBT model and may be useful in screening investigation compounds for the subsequent evaluation in this murine bladder tumor model.",
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