Abstract
In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.
| Original language | English |
|---|---|
| Pages (from-to) | 193-197 |
| Number of pages | 5 |
| Journal | International Journal of Fertility |
| Volume | 25 |
| Issue number | 3 |
| State | Published - Dec 1 1980 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation. / Canales, E. S.; Montvelinsky, H.; Fonseca, E.; Zárate, A.; Kastin, A. J.; Coy, D. H.; Schally, Andrew V.
In: International Journal of Fertility, Vol. 25, No. 3, 01.12.1980, p. 193-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation
AU - Canales, E. S.
AU - Montvelinsky, H.
AU - Fonseca, E.
AU - Zárate, A.
AU - Kastin, A. J.
AU - Coy, D. H.
AU - Schally, Andrew V
PY - 1980/12/1
Y1 - 1980/12/1
N2 - In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.
AB - In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.
UR - http://www.scopus.com/inward/record.url?scp=0019192243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019192243&partnerID=8YFLogxK
M3 - Article
C2 - 6108929
AN - SCOPUS:0019192243
VL - 25
SP - 193
EP - 197
JO - International Journal of Fertility
JF - International Journal of Fertility
SN - 0020-725X
IS - 3
ER -