The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation

E. S. Canales; H. Montvelinsky; E. Fonseca; A. Zárate; A. J. Kastin; D. H. Coy; A. V. Schally

The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation

E. S. Canales, H. Montvelinsky, E. Fonseca, A. Zárate, A. J. Kastin, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	International Journal of Fertility
Volume	25
Issue number	3
State	Published - Dec 1 1980
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

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abstract = "In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.",

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AU - Canales, E. S.

AU - Montvelinsky, H.

AU - Fonseca, E.

AU - Zárate, A.

AU - Kastin, A. J.

AU - Coy, D. H.

AU - Schally, A. V.

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AB - In 25 women with disturbances of ovulation who were treated for sterility with D-Trp-6-LHRH, a potent analog of LHRH, ovulation was achieved in nine patients, but none of these became pregnant after therapy. After using the LHRH analog combined with clomiphene citrate in 14 of these 25 women, six ovulated and only one conceived. The overall rate of ovulation after the combined therapy was better than that obtained when LHRH analog alone was administered. From this study we conclude that more investigations using different regimens have to be carried out in order to establish the clinical benefit of LHRH stimulatory analogs in induction of ovulation.

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The use of a potent stimulatory LHRH analog (D-Trp-6, LHRH) in the induction of ovulation

Abstract

ASJC Scopus subject areas

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