The two faces of pannexins: New roles in inflammation and repair

Helen P. Makarenkova, Sameer B. Shah, Valery I. Shestopalov

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An increasing body of literature on pannexins suggests that these channels play dual and sometimes contradictory roles, contributing to normal cell function, as well as to the pathological progression of disease. In this review, we summarize our understanding of pannexin “protective” and “harmful” functions in inflammation, regeneration and mechanical signaling. We also suggest a possible basis for pannexin’s dual roles, related to extracellular ATP and K+ levels and the activation of various types of P2 receptors that are associated with pannexin. Finally, we speculate upon therapeutic strategies related to pannexin using eyes, lacrimal glands, and peripheral nerves as examples of interesting therapeutic targets.

Original languageEnglish (US)
Pages (from-to)273-288
Number of pages16
JournalJournal of Inflammation Research
StatePublished - Jun 21 2018


  • ATP
  • Inflammation
  • Pannexin
  • Panx1
  • Purinergic signaling
  • Regeneration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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