The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase

Joel C. Eissenberg, Min Gyu Lee, Jessica Schneider, Anne Ilvarsonn, Ramin Shiekhattar, Ali Shilatifard

Research output: Contribution to journalArticle

86 Scopus citations


Histone H3 Lys4 (H3K4) is methylated by yeast Set1-COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalNature Structural and Molecular Biology
Issue number4
StatePublished - Apr 1 2007


ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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