The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase

Joel C. Eissenberg, Min Gyu Lee, Jessica Schneider, Anne Ilvarsonn, Ramin Shiekhattar, Ali Shilatifard

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Histone H3 Lys4 (H3K4) is methylated by yeast Set1-COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalNature Structural and Molecular Biology
Volume14
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Imaginal Discs
Histones
Drosophila
RNA Interference
Drosophila melanogaster
Methylation
Genes
Yeasts
Genome
Proteins

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. / Eissenberg, Joel C.; Lee, Min Gyu; Schneider, Jessica; Ilvarsonn, Anne; Shiekhattar, Ramin; Shilatifard, Ali.

In: Nature Structural and Molecular Biology, Vol. 14, No. 4, 04.2007, p. 344-346.

Research output: Contribution to journalArticle

Eissenberg, Joel C. ; Lee, Min Gyu ; Schneider, Jessica ; Ilvarsonn, Anne ; Shiekhattar, Ramin ; Shilatifard, Ali. / The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. In: Nature Structural and Molecular Biology. 2007 ; Vol. 14, No. 4. pp. 344-346.
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