The treatment of visible signs of senescence

The Italian experience

R. Caputo, M. Monti, S. Motta, M. Barbareschi, Antonella Tosti, R. Serri, C. Rigoni

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

An open clinical study was undertaken to evaluate the anti-photoageing efficacy of topical tretinoin. A length of cream of approximately 1 cm was applied to the face daily in the evening for 6 months: during month 1 of therapy 0.01% tretinoin cream was administered; 0.025% was given during month 2; and 0.05% was given in months 3-6. The clinical symptoms of photoageing (coarse wrinkling, fine wrinkling, skin thinning, mottled hyperpigmentation, laxity and xerosis) were evaluated before and after therapy. A total of 19.1% of patients withdrew from the study; only 5.6% were for treatment-related reasons. At the end of the treatment period all the clinical parameters, except xerosis, were improved. The amount of improvement varied, but only 4.2% of patients failed to show any improvement. Tolerability was excellent in 51.4% of patients, good in 44.4% and fair in 4.2%, and compliance was excellent in 47.0% of patients, good in 48.5% and fair in 4.5%. Tolerability and compliance were improved by applying the same amount of cream each day but increasing the concentration of tretinoin over the 6-month period. Silicone skin replicas of the same area of skin taken before and after treatment, analysed by scanning electron microscopy, profilometry and computer image analysis, showed a decrease in the width of wrinkles, and an improvement in skin texture and follicle density.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalBritish Journal of Dermatology
Volume122
Issue numberSUPPL. 35
StatePublished - Jan 1 1990
Externally publishedYes

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Tretinoin
Skin
Compliance
Skin Aging
Therapeutics
Hyperpigmentation
Silicones
Electron Scanning Microscopy

ASJC Scopus subject areas

  • Dermatology

Cite this

Caputo, R., Monti, M., Motta, S., Barbareschi, M., Tosti, A., Serri, R., & Rigoni, C. (1990). The treatment of visible signs of senescence: The Italian experience. British Journal of Dermatology, 122(SUPPL. 35), 97-103.

The treatment of visible signs of senescence : The Italian experience. / Caputo, R.; Monti, M.; Motta, S.; Barbareschi, M.; Tosti, Antonella; Serri, R.; Rigoni, C.

In: British Journal of Dermatology, Vol. 122, No. SUPPL. 35, 01.01.1990, p. 97-103.

Research output: Contribution to journalArticle

Caputo, R, Monti, M, Motta, S, Barbareschi, M, Tosti, A, Serri, R & Rigoni, C 1990, 'The treatment of visible signs of senescence: The Italian experience', British Journal of Dermatology, vol. 122, no. SUPPL. 35, pp. 97-103.
Caputo R, Monti M, Motta S, Barbareschi M, Tosti A, Serri R et al. The treatment of visible signs of senescence: The Italian experience. British Journal of Dermatology. 1990 Jan 1;122(SUPPL. 35):97-103.
Caputo, R. ; Monti, M. ; Motta, S. ; Barbareschi, M. ; Tosti, Antonella ; Serri, R. ; Rigoni, C. / The treatment of visible signs of senescence : The Italian experience. In: British Journal of Dermatology. 1990 ; Vol. 122, No. SUPPL. 35. pp. 97-103.
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