The treatment of agitation during initial hospitalization after traumatic brain injury

Marvin M. Brooke, David R. Patterson, Kent A. Questad, Diana Cardenas, Lisa Farrel-Roberts

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Agitation after traumatic brain injury is disruptive for patient care, distressing, and difficult to treat. The use of propranolol has been advocated to control agitation after brain injury. It reportedly lacks some of the deleterious cognitive and emotional effects of other medications and physical restraints. This study was designed to test if propranolol is effective in reducing agitated behavior. Subjects had traumatic closed-head injury treated at a combined Level I Trauma Center and Rehabilitation Center. Twenty-one subjects met the criteria of agitation and were treated with propranolol or placebo in a double-blind fashion. The intensity of agitation was significantly lower in the treatment group although the number of episodes were similar. The use of restraints was also significantly lower in the treatment group. The results support the effectiveness of propranolol in reducing the intensity of agitation during the initial hospitalization after closed-head injury.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalArchives of Physical Medicine and Rehabilitation
Volume73
Issue number10
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Propranolol
Hospitalization
Closed Head Injuries
Physical Restraint
Rehabilitation Centers
Trauma Centers
Therapeutics
Brain Injuries
Patient Care
Placebos
Traumatic Brain Injury

Keywords

  • Agitation
  • Brain injury
  • Propranolol

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Brooke, M. M., Patterson, D. R., Questad, K. A., Cardenas, D., & Farrel-Roberts, L. (1992). The treatment of agitation during initial hospitalization after traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 73(10), 917-921.

The treatment of agitation during initial hospitalization after traumatic brain injury. / Brooke, Marvin M.; Patterson, David R.; Questad, Kent A.; Cardenas, Diana; Farrel-Roberts, Lisa.

In: Archives of Physical Medicine and Rehabilitation, Vol. 73, No. 10, 01.01.1992, p. 917-921.

Research output: Contribution to journalArticle

Brooke, MM, Patterson, DR, Questad, KA, Cardenas, D & Farrel-Roberts, L 1992, 'The treatment of agitation during initial hospitalization after traumatic brain injury', Archives of Physical Medicine and Rehabilitation, vol. 73, no. 10, pp. 917-921.
Brooke MM, Patterson DR, Questad KA, Cardenas D, Farrel-Roberts L. The treatment of agitation during initial hospitalization after traumatic brain injury. Archives of Physical Medicine and Rehabilitation. 1992 Jan 1;73(10):917-921.
Brooke, Marvin M. ; Patterson, David R. ; Questad, Kent A. ; Cardenas, Diana ; Farrel-Roberts, Lisa. / The treatment of agitation during initial hospitalization after traumatic brain injury. In: Archives of Physical Medicine and Rehabilitation. 1992 ; Vol. 73, No. 10. pp. 917-921.
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