The Transcription Map of the 13q14 Region Frequently Deleted in B-cell Chronic Lymphocytic Leukemia

T. V. Tyazhelova, D. V. Ivanov, N. V. Makeeva, B. I. Kapanadze, E. A. Nikitin, A. B. Semov, O. Sangfelt, D. Grander, A. I. Vorobiev, S. Einhorn, N. K. Yankovsky, A. V. Baranova

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Deletions in the region located between the STS markers D 13S1168 and D13S25 on chromosome 13 are the most frequent genomic changes in patients with B-cell chronic lymphocytic leukemia (B-CLL). After sequencing of this region, two novel candidate genes were identified: C13orf1 (chromosome 13 open reading frame 1) and PLCC (putative large CLL candidate). Analysis of the repeat distribution revealed two subregions differing in composition of repetitious DNA and gene organization. The interval D13S1168-D13S319 contains 131 Alu repeats accounting for 24.8% of its length, whereas the interval GCT16C05-D13S25, which is no more than 180 kb away from the former one is extremely poor in Alu repeats (4.1 % of the total length). Both intervals contain almost the same amount of the LINE-type repeats L1 and L2 (20.3 and 21.24%, respectively). In the chromosomal region studied, 29 Alu repeats were found to belong to the evolutionary young subfamily Y, which is still capable of amplifying. A considerable proportion of repeats of this type with similar nucleotide sequences may contribute to the recombinational activity of the chromosomal region 13q 14.3, which is responsible for its rearrangements in some tumors in humans.

Original languageEnglish (US)
Pages (from-to)1286-1292
Number of pages7
JournalRussian Journal of Genetics
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Tyazhelova, T. V., Ivanov, D. V., Makeeva, N. V., Kapanadze, B. I., Nikitin, E. A., Semov, A. B., Sangfelt, O., Grander, D., Vorobiev, A. I., Einhorn, S., Yankovsky, N. K., & Baranova, A. V. (2001). The Transcription Map of the 13q14 Region Frequently Deleted in B-cell Chronic Lymphocytic Leukemia. Russian Journal of Genetics, 37(11), 1286-1292. https://doi.org/10.1023/A:1012561109880