TY - JOUR
T1 - The transcription factor LMO2 is a robust marker of vascular endothelium and vascular neoplasms and selected other entities
AU - Gratzinger, Dita
AU - Zhao, Shuchun
AU - West, Robert
AU - Rouse, Robert V.
AU - Vogel, Hannes
AU - Gil, Elena Cubedo
AU - Levy, Ronald
AU - Lossos, Izidore S.
AU - Natkunam, Yasodha
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2009/2
Y1 - 2009/2
N2 - The transcription factor LMO2 is involved in vascular and hematopoietic development and hematolymphoid neoplasia. We have demonstrated that LMO2 is expressed nearly ubiquitously in native and neoplastic vasculature, including lymphatics. LMO2 reactivity is otherwise virtually absent in nonhematolymphoid tissues except in breast myoepithelium, prostatic basal cells, and secretory phase endometrial glands. Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma. LMO2 is uniformly expressed in benign vascular and lymphatic neoplasms and in most malignant vascular neoplasms with the exception of epithelioid vascular neoplasms of pleura and bone. Among nonvascular neoplasms, LMO2 reactivity is present in giant cell tumor of tendon sheath, juvenile xanthogranuloma, a subset of gastrointestinal stromal tumors, small round blue cell tumors, and myoepithelial-derived neoplasms. The restricted expression pattern, nuclear localization, and crisp staining of LMO2 in paraffin blocks make it an attractive candidate for the diagnostic immunohistochemistry laboratory.
AB - The transcription factor LMO2 is involved in vascular and hematopoietic development and hematolymphoid neoplasia. We have demonstrated that LMO2 is expressed nearly ubiquitously in native and neoplastic vasculature, including lymphatics. LMO2 reactivity is otherwise virtually absent in nonhematolymphoid tissues except in breast myoepithelium, prostatic basal cells, and secretory phase endometrial glands. Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma. LMO2 is uniformly expressed in benign vascular and lymphatic neoplasms and in most malignant vascular neoplasms with the exception of epithelioid vascular neoplasms of pleura and bone. Among nonvascular neoplasms, LMO2 reactivity is present in giant cell tumor of tendon sheath, juvenile xanthogranuloma, a subset of gastrointestinal stromal tumors, small round blue cell tumors, and myoepithelial-derived neoplasms. The restricted expression pattern, nuclear localization, and crisp staining of LMO2 in paraffin blocks make it an attractive candidate for the diagnostic immunohistochemistry laboratory.
KW - Angiosarcoma
KW - Endothelium
KW - Gastrointestinal stromal tumor
KW - Giant cell tumor of tendon sheath
KW - LMO2
KW - Myoepithelial
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U2 - 10.1309/AJCP5FP3NAXAXRJE
DO - 10.1309/AJCP5FP3NAXAXRJE
M3 - Article
C2 - 19141387
AN - SCOPUS:58849151863
VL - 131
SP - 264
EP - 278
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 2
ER -