The time course of vasogenic oedema after focal human head injury--evidence from SPECT mapping of blood brain barrier defects.

Ross Bullock, P. Statham, J. Patterson, D. Wyper, D. Hadley, E. Teasdale

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We have tomographically mapped changes in the blood brain barrier (BBB) (99 mTc Pertechnetate) in 20 patients with acute contusions, and four with acute subdural haematomas in situ. The changes were related to regional CBF, (99 mTc HMPAO SPECT) T2 weighted MRI scans, CT abnormalities and the clinical features. Seventy-five percent of contusions were accompanied by a BBB abnormality, usually a "halo" around the lesion, which was more common in scans made after the second day. All contusions demonstrated "oedema" as a zone of "T2" signal on MRI or a zone of lucency on CT, and all were accompanied by a focal zone of low CBF on SPECT. Early contusional oedema appears to be cytotoxic but in certain cases, delayed blood brain barrier lesions develop, suggesting a vasogenic component.

Original languageEnglish
Pages (from-to)286-288
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume51
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

blood-brain barrier
edema
Contusions
Single-Photon Emission-Computed Tomography
Blood-Brain Barrier
Craniocerebral Trauma
Edema
abnormalities
lesions
Defects
defects
Hematoma, Subdural, Acute
Sodium Pertechnetate Tc 99m
Magnetic resonance imaging
halos
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

The time course of vasogenic oedema after focal human head injury--evidence from SPECT mapping of blood brain barrier defects. / Bullock, Ross; Statham, P.; Patterson, J.; Wyper, D.; Hadley, D.; Teasdale, E.

In: Acta Neurochirurgica, Supplement, Vol. 51, 01.12.1990, p. 286-288.

Research output: Contribution to journalArticle

Bullock, Ross ; Statham, P. ; Patterson, J. ; Wyper, D. ; Hadley, D. ; Teasdale, E. / The time course of vasogenic oedema after focal human head injury--evidence from SPECT mapping of blood brain barrier defects. In: Acta Neurochirurgica, Supplement. 1990 ; Vol. 51. pp. 286-288.
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