The thiadiazinone EMD 57033 speeds the activation of skinned cardiac muscle produced by the photolysis of nitr-5

S. J. Simnett, S. Lipscomb, C. C. Ashley, J. D. Potter, I. P. Mulligan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

EMD 57033 is thought to produce its potentiating effect by increasing the apparent Ca2+ sensitivity of the myofilaments, possibly by altering the kinetics of actomyosin interaction. We have investigated the effect of 10μM EMD 57033 upon activation speed, induced by flash photolysis of 2mM nitr-5 (caged Ca2+), in chemically skinned trabeculae from the guinea-pig at 12°C. EMD 57033 increases the half time of activation from 238±18.5 msec (n=6) to 132.1± 34.0 msec (n=8)(mean ± s.e.m.) and suggests that this Ca2+ sensitiser has an important effect upon fapp, that is the transition from the non-force to force generating cross-bridge states.

Original languageEnglish (US)
Pages (from-to)550-552
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume427
Issue number5-6
DOIs
StatePublished - Jul 1 1994

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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