The tau H2 haplotype is almost exclusively Caucasian in origin

Whitney Evans, Hon Chung Fung, John Steele, Johanna Eerola, Pentti Tienari, Alan Pittman, Rohan De Silva, Amanda Myers, Fabienne Wavrant De Vrieze, Andrew Singleton, John Hardy

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalNeuroscience Letters
Issue number3
StatePublished - Oct 21 2004
Externally publishedYes


  • Corticobasal degeneration
  • FTDP-17
  • MAPT gene
  • Neurofibrillary tangles
  • Parkinsonism
  • Populations genetics
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)


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