The tau H2 haplotype is almost exclusively Caucasian in origin

Whitney Evans, Hon Chung Fung, John Steele, Johanna Eerola, Pentti Tienari, Alan Pittman, Rohan De Silva, Amanda J Myers, Fabienne Wavrant De Vrieze, Andrew Singleton, John Hardy

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalNeuroscience Letters
Volume369
Issue number3
DOIs
StatePublished - Oct 21 2004
Externally publishedYes

Fingerprint

Haplotypes
Tauopathies
Epidemiology

Keywords

  • Corticobasal degeneration
  • FTDP-17
  • MAPT gene
  • Neurofibrillary tangles
  • Parkinsonism
  • Populations genetics
  • Progressive supranuclear palsy
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evans, W., Fung, H. C., Steele, J., Eerola, J., Tienari, P., Pittman, A., ... Hardy, J. (2004). The tau H2 haplotype is almost exclusively Caucasian in origin. Neuroscience Letters, 369(3), 183-185. https://doi.org/10.1016/j.neulet.2004.05.119

The tau H2 haplotype is almost exclusively Caucasian in origin. / Evans, Whitney; Fung, Hon Chung; Steele, John; Eerola, Johanna; Tienari, Pentti; Pittman, Alan; Silva, Rohan De; Myers, Amanda J; Vrieze, Fabienne Wavrant De; Singleton, Andrew; Hardy, John.

In: Neuroscience Letters, Vol. 369, No. 3, 21.10.2004, p. 183-185.

Research output: Contribution to journalArticle

Evans, W, Fung, HC, Steele, J, Eerola, J, Tienari, P, Pittman, A, Silva, RD, Myers, AJ, Vrieze, FWD, Singleton, A & Hardy, J 2004, 'The tau H2 haplotype is almost exclusively Caucasian in origin', Neuroscience Letters, vol. 369, no. 3, pp. 183-185. https://doi.org/10.1016/j.neulet.2004.05.119
Evans W, Fung HC, Steele J, Eerola J, Tienari P, Pittman A et al. The tau H2 haplotype is almost exclusively Caucasian in origin. Neuroscience Letters. 2004 Oct 21;369(3):183-185. https://doi.org/10.1016/j.neulet.2004.05.119
Evans, Whitney ; Fung, Hon Chung ; Steele, John ; Eerola, Johanna ; Tienari, Pentti ; Pittman, Alan ; Silva, Rohan De ; Myers, Amanda J ; Vrieze, Fabienne Wavrant De ; Singleton, Andrew ; Hardy, John. / The tau H2 haplotype is almost exclusively Caucasian in origin. In: Neuroscience Letters. 2004 ; Vol. 369, No. 3. pp. 183-185.
@article{741348590f984ac8801afcbfa4952ce1,
title = "The tau H2 haplotype is almost exclusively Caucasian in origin",
abstract = "We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.",
keywords = "Corticobasal degeneration, FTDP-17, MAPT gene, Neurofibrillary tangles, Parkinsonism, Populations genetics, Progressive supranuclear palsy, Tau",
author = "Whitney Evans and Fung, {Hon Chung} and John Steele and Johanna Eerola and Pentti Tienari and Alan Pittman and Silva, {Rohan De} and Myers, {Amanda J} and Vrieze, {Fabienne Wavrant De} and Andrew Singleton and John Hardy",
year = "2004",
month = "10",
day = "21",
doi = "10.1016/j.neulet.2004.05.119",
language = "English",
volume = "369",
pages = "183--185",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The tau H2 haplotype is almost exclusively Caucasian in origin

AU - Evans, Whitney

AU - Fung, Hon Chung

AU - Steele, John

AU - Eerola, Johanna

AU - Tienari, Pentti

AU - Pittman, Alan

AU - Silva, Rohan De

AU - Myers, Amanda J

AU - Vrieze, Fabienne Wavrant De

AU - Singleton, Andrew

AU - Hardy, John

PY - 2004/10/21

Y1 - 2004/10/21

N2 - We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.

AB - We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.

KW - Corticobasal degeneration

KW - FTDP-17

KW - MAPT gene

KW - Neurofibrillary tangles

KW - Parkinsonism

KW - Populations genetics

KW - Progressive supranuclear palsy

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=4644372063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644372063&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.05.119

DO - 10.1016/j.neulet.2004.05.119

M3 - Article

VL - 369

SP - 183

EP - 185

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -