The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

Yongchun Hou; Xuejun Wu; Wenhua Xie; Paul G. Braunschweiger; Peng G. Wang

doi:10.1016/S0040-4039(00)02158-4

The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

Yongchun Hou, Xuejun Wu, Wenhua Xie, Paul G. Braunschweiger, Peng G. Wang

Radiation Oncology

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30 Scopus citations

Abstract

An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.

Original language	English (US)
Pages (from-to)	825-829
Number of pages	5
Journal	Tetrahedron Letters
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/S0040-4039(00)02158-4
State	Published - Jan 29 2001

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ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Hou, Y., Wu, X., Xie, W., Braunschweiger, P. G., & Wang, P. G. (2001). The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor. Tetrahedron Letters, 42(5), 825-829. https://doi.org/10.1016/S0040-4039(00)02158-4

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10.1016/S0040-4039(00)02158-4