The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

Yongchun Hou, Xuejun Wu, Wenhua Xie, Paul G Braunschweiger, Peng G. Wang

Research output: Contribution to journal › Article

30 Citations (Scopus)

Abstract

An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.

Original languageEnglish
Pages (from-to)825-829
Number of pages5
JournalTetrahedron Letters
Volume42
Issue number5
DOIs
StatePublished - Jan 29 2001

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Nitric Oxide Donors
Cytotoxicity
Fructose
S-Nitroso-N-Acetylpenicillamine
Prostatic Neoplasms
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor. / Hou, Yongchun; Wu, Xuejun; Xie, Wenhua; Braunschweiger, Paul G; Wang, Peng G.

In: Tetrahedron Letters, Vol. 42, No. 5, 29.01.2001, p. 825-829.

Research output: Contribution to journal › Article

Hou, Y, Wu, X, Xie, W, Braunschweiger, PG & Wang, PG 2001, 'The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor', Tetrahedron Letters, vol. 42, no. 5, pp. 825-829. https://doi.org/10.1016/S0040-4039(00)02158-4
Hou Y, Wu X, Xie W, Braunschweiger PG, Wang PG. The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor. Tetrahedron Letters. 2001 Jan 29;42(5):825-829. https://doi.org/10.1016/S0040-4039(00)02158-4
Hou, Yongchun ; Wu, Xuejun ; Xie, Wenhua ; Braunschweiger, Paul G ; Wang, Peng G. / The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 5. pp. 825-829.
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