Abstract
An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.
Original language | English (US) |
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Pages (from-to) | 825-829 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 42 |
Issue number | 5 |
DOIs | |
State | Published - Jan 29 2001 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry