The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

Yongchun Hou, Xuejun Wu, Wenhua Xie, Paul G. Braunschweiger, Peng G. Wang

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.

Original languageEnglish (US)
Pages (from-to)825-829
Number of pages5
JournalTetrahedron Letters
Volume42
Issue number5
DOIs
StatePublished - Jan 29 2001

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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