Abstract
The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.
| Original language | English |
|---|---|
| Pages (from-to) | 1157-1165 |
| Number of pages | 9 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 1 2011 |
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Keywords
- Autoimmunity
- Cytoplasmic DNA
- Interferon
- STING
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Molecular Medicine
- Pharmacology
- Cellular and Molecular Neuroscience
Cite this
The STING pathway and regulation of innate immune signaling in response to DNA pathogens. / Ishikawa, Hiroki; Barber, Glen N.
In: Cellular and Molecular Life Sciences, Vol. 68, No. 7, 01.04.2011, p. 1157-1165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The STING pathway and regulation of innate immune signaling in response to DNA pathogens
AU - Ishikawa, Hiroki
AU - Barber, Glen N
PY - 2011/4/1
Y1 - 2011/4/1
N2 - The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.
AB - The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.
KW - Autoimmunity
KW - Cytoplasmic DNA
KW - Interferon
KW - STING
UR - http://www.scopus.com/inward/record.url?scp=79953705058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953705058&partnerID=8YFLogxK
U2 - 10.1007/s00018-010-0605-2
DO - 10.1007/s00018-010-0605-2
M3 - Article
VL - 68
SP - 1157
EP - 1165
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 7
ER -