The STING pathway and regulation of innate immune signaling in response to DNA pathogens

Hiroki Ishikawa, Glen N Barber

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.

Original languageEnglish
Pages (from-to)1157-1165
Number of pages9
JournalCellular and Molecular Life Sciences
Volume68
Issue number7
DOIs
StatePublished - Apr 1 2011

Fingerprint

Interferons
DNA
Inflammasomes
Genes
Toll-Like Receptors
Virus Diseases
Endoplasmic Reticulum
Immune System
Nucleotides
Neoplasms

Keywords

  • Autoimmunity
  • Cytoplasmic DNA
  • Interferon
  • STING

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

The STING pathway and regulation of innate immune signaling in response to DNA pathogens. / Ishikawa, Hiroki; Barber, Glen N.

In: Cellular and Molecular Life Sciences, Vol. 68, No. 7, 01.04.2011, p. 1157-1165.

Research output: Contribution to journalArticle

@article{7aba557eb4964bda9c8b0f5e8c1b8e11,
title = "The STING pathway and regulation of innate immune signaling in response to DNA pathogens",
abstract = "The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.",
keywords = "Autoimmunity, Cytoplasmic DNA, Interferon, STING",
author = "Hiroki Ishikawa and Barber, {Glen N}",
year = "2011",
month = "4",
day = "1",
doi = "10.1007/s00018-010-0605-2",
language = "English",
volume = "68",
pages = "1157--1165",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "7",

}

TY - JOUR

T1 - The STING pathway and regulation of innate immune signaling in response to DNA pathogens

AU - Ishikawa, Hiroki

AU - Barber, Glen N

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.

AB - The innate immune system has evolved a variety of sensing mechanisms to detect and counter microbial invasion. These include the Toll-like receptor (TLR), cytoplasmic, nucleotide binding oligomerization domain (NOD)-like receptor and RIG-I-like helicase (RLH) pathways. However, how the cell detects pathogen-associated DNA to trigger host defense, including the production of interferon, remains to be fully clarified. Understanding these processes could have profound implications into how we understand and treat a variety of microbial-related disease, including viral-associated cancers, as well as autoimmune disorders. Recently, an endoplasmic reticulum-associated molecule referred to as STING (for stimulator of interferon genes) was isolated and shown to be critical for regulating the production of IFN in response to cytoplasmic DNA. Here, we review recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes.

KW - Autoimmunity

KW - Cytoplasmic DNA

KW - Interferon

KW - STING

UR - http://www.scopus.com/inward/record.url?scp=79953705058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953705058&partnerID=8YFLogxK

U2 - 10.1007/s00018-010-0605-2

DO - 10.1007/s00018-010-0605-2

M3 - Article

VL - 68

SP - 1157

EP - 1165

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 7

ER -